Evidence map›Paper›PMID 35518290›Full record

ArticleRSC advances2020

The development of peptide-boron difluoride formazanate conjugates as fluorescence imaging agents.

Neha Sharma, Stephanie M Barbon, Tyler Lalonde, Ryan R Maar, Mark Milne, Joe B Gilroy, Leonard G Luyt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Real-Time Detection of Burn Wound Infection via a Turn-On NIR-II Fluorescent Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Neha SharmaDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.
Stephanie M BarbonDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.
Tyler LalondeDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.
Ryan R MaarDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.
Mark MilneLondon Regional Cancer Program, Lawson Health Research Institute 800 Commissioners Road East London Ontario N6A 5W9 Canada.
Joe B GilroyDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.ORCID https://orcid.org/0000-0003-0349-7780
Leonard G LuytDepartment of Chemistry, University of Western Ontario 1151 Richmond Street London Ontario N6A 5B7 Canada joe.gilroy@uwo.ca lluyt@uwo.ca.ORCID https://orcid.org/0000-0002-0941-4731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new fluorescence imaging probes have been synthesized by incorporating a versatile alkyne-substituted boron difluoride formazanate precursor with peptides through copper-catalyzed alkyne-azide cycloaddition. The formazanate dye was appended to a C-terminal amino acid of ghrelin for imaging the growth hormone secretagogue receptor (GHSR-1a). To demonstrate versatile bioconjugation chemistry, the formazanate dye was added to the N-terminus of bombesin for targeting the gastrin releasing peptide receptor (GRPR). These are the first examples of using this emerging class of dyes, boron difluoride formazanates, for the labelling of biomolecules.

Identifiers

PMID35518290
PMCPMC9053952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.