Evidence map›Paper›PMID 35517756›Full record

ArticleRSC advances2020

Preparation, characterization and evaluation of a new film based on chitosan, arginine and gold nanoparticle derivatives for wound-healing efficacy.

Kai Wang, Zhiping Qi, Su Pan, Shuang Zheng, Haosheng Wang, YuXin Chang, Hongru Li, Pan Xue, Xiaoyu Yang, Chuan Fu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. An Updated Review on Silver Nanoparticles in Biomedicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kai WangThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.ORCID https://orcid.org/0000-0001-6431-9422
Zhiping QiThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.ORCID https://orcid.org/0000-0003-4898-104X
Su PanThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Shuang ZhengThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Haosheng WangThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
YuXin ChangThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Hongru LiThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Pan XueThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Xiaoyu YangThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Chuan FuThe Second Hospital of Jilin University Changchun Jilin 130041 China yangxiaoy@jlu.edu.cn fuchuan2015@163.com.
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well-known that the combination of polymers and nanoparticles (NPs) provides optimised wound dressing and accelerates wound healing. The knowledge about the structure and properties of these materials is of critical importance in biological processes related to wound healing. In this study, we prepared a chitosan (CS) film modified with arginine (Arg) and gold NPs (AuNPs) and investigated its effectiveness as a dressing material for wound healing. Fourier-transform infrared spectroscopy (FTIR) confirmed that Arg was successfully grafted on CS. The resultant CS-Arg/AuNP film was then characterised by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The modification of Arg and AuNPs improved the hydrophilicity, mechanical strength and antibacterial properties of the film, which in turn provided an enhanced ideal environment for cell adhesion and proliferation. Cell Counting Kit-8 (CCK-8) was used to demonstrate the survival rate. Furthermore, the proteins involved in wound healing were evaluated qualitatively and quantitatively by immunofluorescence and western blotting, respectively. The skin defect models used for the

Identifiers

PMID35517756
PMCPMC9054353
OpenAlexW3033313015

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.