Evidence map›Paper›PMID 35517682›Full record

ReviewRSC advances2019

A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors.

Siva Kumar Krishnan, Eric Singh, Pragya Singh, Meyya Meyyappan, Hari Singh Nalwa

Abstract readReview
In one paragraph

Review in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Advanced electrochemical biosensing exploiting mussel-inspired polydopamine interfaces.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Review
  10. Screen-Printed Carbon Electrode Modified with ZrOMolecules (Basel, Switzerland) · 2026
    Article
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siva Kumar KrishnanCONACYT-Instituto de Física, Benemérita Universidad Autónoma de Puebla Apdo. Postal J-48 Puebla 72570 Mexico.ORCID https://orcid.org/0000-0002-9672-9335
Eric SinghDepartment of Computer Science, Stanford University Stanford California 94305 USA.ORCID https://orcid.org/0000-0001-7344-4495
Pragya SinghDepartment of Electrical Engineering and Computer Science, National Chiao Tung University Hsinchu 30010 Taiwan.ORCID https://orcid.org/0000-0002-0631-3871
Meyya MeyyappanCenter for Nanotechnology, NASA Ames Research Center, Moffett Field Mountain View California 94035 USA m.meyyappan@nasa.gov.
Hari Singh NalwaAdvanced Technology Research 26650 The Old Road Valencia California 91381 USA nalwa@mindspring.com.ORCID https://orcid.org/0000-0002-8867-918X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosensors with high sensitivity, selectivity and a low limit of detection, reaching nano/picomolar concentrations of biomolecules, are important to the medical sciences and healthcare industry for evaluating physiological and metabolic parameters. Over the last decade, different nanomaterials have been exploited to design highly efficient biosensors for the detection of analyte biomolecules. The discovery of graphene has spectacularly accelerated research on fabricating low-cost electrode materials because of its unique physical properties, including high specific surface area, high carrier mobility, high electrical conductivity, flexibility, and optical transparency. Graphene and its oxygenated derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), are becoming an important class of nanomaterials in the field of biosensors. The presence of oxygenated functional groups makes GO nanosheets strongly hydrophilic, facilitating chemical functionalization. Graphene, GO and rGO nanosheets can be easily combined with various types of inorganic nanoparticles, including metals, metal oxides, semiconducting nanoparticles, quantum dots, organic polymers and biomolecules, to create a diverse range of graphene-based nanocomposites with enhanced sensitivity for biosensor applications. This review summarizes the advances in two-dimensional (2D) and three-dimensional (3D) graphene-based nanocomposites as emerging electrochemical and fluorescent biosensing platforms for the detection of a wide range of biomolecules with enhanced sensitivity, selectivity and a low limit of detection. The biofunctionalization and nanocomposite formation processes of graphene-based materials and their unique properties, surface functionalization, enzyme immobilization strategies, covalent immobilization, physical adsorption, biointeractions and direct electron transfer (DET) processes are discussed in connection with the design and fabrication of biosensors. The enzymatic and nonenzymatic reactions on graphene-based nanocomposite surfaces for glucose- and cholesterol-related electrochemical biosensors are analyzed. This review covers a very broad range of graphene-based electrochemical and fluorescent biosensors for the detection of glucose, cholesterol, hydrogen peroxide (H

Identifiers

PMID35517682
PMCPMC9062009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.