Evidence map›Paper›PMID 35517573›Full record

ReviewFrontiers in behavioral neuroscience2022

The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.

Caroline B Palavicino-Maggio, Saheli Sengupta

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Frontiers in behavioral neuroscience · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Caroline B Palavicino-MaggioBasic Neuroscience Division, Department of Psychiatry, Harvard Medical School, McLean Hospital, Boston, MA, United States.
Saheli SenguptaBasic Neuroscience Division, Department of Psychiatry, Harvard Medical School, McLean Hospital, Boston, MA, United States.
Harvard University · USMcLean Hospital · US

Funding

Aggression in Drosophila: circuitry involved; learning and memory accompanying aggression; and establishing the circuitry of high-level aggression in the brainR35GM118137 · NIGMS · HARVARD MEDICAL SCHOOL · PI KRAVITZ, EDWARD A · 2016 to 2022
$4.0M
Unraveling the neural basis of female aggression and dementia-related aggression: a systems biology approach.R00GM141449 · NIGMS · MCLEAN HOSPITAL · PI PALAVICINO-MAGGIO, CAROLINE · 2022 to 2024
$922k
Unraveling the neural basis of female aggression and dementia-related aggression: a systems biology approach.K99GM141449 · NIGMS · HARVARD MEDICAL SCHOOL · PI PALAVICINO-MAGGIO, CAROLINE · 2021 to 2022
$108k
NIGMS NIH HHS K99 GM141449NIGMS NIH HHS R35 GM118137
6 · The paper itself

Abstract

Aggression is an intrinsic trait that organisms of almost all species, humans included, use to get access to food, shelter, and mating partners. To maximize fitness in the wild, an organism must vary the intensity of aggression toward the same or different stimuli. How much of this variation is genetic and how much is externally induced, is largely unknown but is likely to be a combination of both. Irrespective of the source, one of the principal physiological mechanisms altering the aggression intensity involves neuromodulation. Any change or variation in aggression intensity is most likely governed by a complex interaction of several neuromodulators acting via a meshwork of neural circuits. Resolving aggression-specific neural circuits in a mammalian model has proven challenging due to the highly complex nature of the mammalian brain. In that regard, the fruit fly model

Indexed as

acetylcholineaggressiondopamineDrosophila melanogasterneuromodulatoroctopaminepeptidesserotonin

Identifiers

PMID35517573
PMCPMC9062135
OpenAlexW4224219500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.