Evidence map›Paper›PMID 35517563›Full record

ArticleRSC advances2020

Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity.

Ana Carolina Ruberte, Carlos Aydillo, Arun K Sharma, Carmen Sanmartín, Daniel Plano

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Ana Carolina RuberteUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas Irunla-rrea 1 E-31008 Pamplona Spain sanmartin@unav.es +34-948425600 ext. 806388.ORCID https://orcid.org/0000-0001-8818-3136
Carlos AydilloUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas Irunla-rrea 1 E-31008 Pamplona Spain sanmartin@unav.es +34-948425600 ext. 806388.
Arun K SharmaPenn State College of Medicine, Penn State Cancer Institute, CH72, Department of Pharmacology 500 University Drive Hershey Pennsylvania 17033 USA.
Carmen SanmartínUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas Irunla-rrea 1 E-31008 Pamplona Spain sanmartin@unav.es +34-948425600 ext. 806388.ORCID https://orcid.org/0000-0003-3431-7826
Daniel PlanoUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas Irunla-rrea 1 E-31008 Pamplona Spain sanmartin@unav.es +34-948425600 ext. 806388.ORCID https://orcid.org/0000-0002-8266-0445
Sociedad Española de Endocrinología y Nutrición · ESHershey (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

Identifiers

PMID35517563
PMCPMC9057275
OpenAlexW3092820422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.