Evidence map›Paper›PMID 35517286›Full record

ArticleRSC advances2019

Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine.

Yuanfeng Wei, Jianjun Zhang, Yazhen Zheng, Yaxiang Gong, Meng Fu, Chengran Liu, Liang Xu, Changquan Calvin Sun, Yuan Gao, Shuai Qian

Abstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanfeng WeiSchool of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009 China newgaoyuan@163.com silence_qs@163.com +86 25 83379418 +86 25 83379418 +86 139 15957175.
Jianjun ZhangSchool of Pharmacy, China Pharmaceutical University Nanjing 210009 China.
Yazhen ZhengSchool of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009 China newgaoyuan@163.com silence_qs@163.com +86 25 83379418 +86 25 83379418 +86 139 15957175.
Yaxiang GongSchool of Pharmacy, China Pharmaceutical University Nanjing 210009 China.
Meng FuSchool of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009 China newgaoyuan@163.com silence_qs@163.com +86 25 83379418 +86 25 83379418 +86 139 15957175.
Chengran LiuSchool of Pharmacy, China Pharmaceutical University Nanjing 210009 China.
Liang XuSchool of Pharmacy, China Pharmaceutical University Nanjing 210009 China.
Changquan Calvin SunDepartment of Pharmaceutics, College of Pharmacy, University of Minnesota Minneapolis MN 55455 USA.ORCID https://orcid.org/0000-0001-7284-5334
Yuan GaoSchool of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009 China newgaoyuan@163.com silence_qs@163.com +86 25 83379418 +86 25 83379418 +86 139 15957175.
Shuai QianSchool of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 210009 China newgaoyuan@163.com silence_qs@163.com +86 25 83379418 +86 25 83379418 +86 139 15957175.ORCID https://orcid.org/0000-0003-1961-4128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aims to develop cubosomes with surface cross-linked chitosan for sustained drug delivery and enhanced oral bioavailability of vinpocetine (VPT). GMO based liquid cubosomes with VPT loading were prepared by the high pressure homogenization method. In order to enhance the anti-digestion effect, chitosan was cross-linked on cubosomes by the Schiff reaction, followed by solidification

Identifiers

PMID35517286
PMCPMC9060951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.