Evidence map›Paper›PMID 35517048›Full record

ReviewFrontiers in aging neuroscience2022

The Roles of Optogenetics and Technology in Neurobiology: A Review.

Wenqing Chen, Chen Li, Wanmin Liang, Yunqi Li, Zhuoheng Zou, Yunxuan Xie, Yangzeng Liao, Lin Yu, Qianyi Lin, Meiying Huang and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. From Biophysics to Biomedical Physics.ACS bio & med chem Au · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Targeting the insular cortex for neuropathic pain modulation: Insights into synaptic and neuronal mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenqing ChenDepartment of Laboratory Medicine, Hangzhou Medical College, Hangzhou, China.
Chen LiDepartment of Biology, Chemistry, Pharmacy, Free University of Berlin, Berlin, Germany.
Wanmin LiangZhu's Team, Guangdong Medical University, Zhanjiang, China.
Yunqi LiZhu's Team, Guangdong Medical University, Zhanjiang, China.
Zhuoheng ZouZhu's Team, Guangdong Medical University, Zhanjiang, China.
Yunxuan XieZhu's Team, Guangdong Medical University, Zhanjiang, China.
Yangzeng LiaoZhu's Team, Guangdong Medical University, Zhanjiang, China.
Lin YuZhu's Team, Guangdong Medical University, Zhanjiang, China.
Qianyi LinZhu's Team, Guangdong Medical University, Zhanjiang, China.
Meiying HuangZhu's Team, Guangdong Medical University, Zhanjiang, China.
Zesong LiGuangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, China.
Xiao ZhuDepartment of Laboratory Medicine, Hangzhou Medical College, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optogenetic is a technique that combines optics and genetics to control specific neurons. This technique usually uses adenoviruses that encode photosensitive protein. The adenovirus may concentrate in a specific neural region. By shining light on the target nerve region, the photosensitive protein encoded by the adenovirus is controlled. Photosensitive proteins controlled by light can selectively allow ions inside and outside the cell membrane to pass through, resulting in inhibition or activation effects. Due to the high precision and minimally invasive, optogenetics has achieved good results in many fields, especially in the field of neuron functions and neural circuits. Significant advances have also been made in the study of many clinical diseases. This review focuses on the research of optogenetics in the field of neurobiology. These include how to use optogenetics to control nerve cells, study neural circuits, and treat diseases by changing the state of neurons. We hoped that this review will give a comprehensive understanding of the progress of optogenetics in the field of neurobiology.

Indexed as

nanoparticlesnervous systemneural circuitsneurobiologyneuronoptogenetics

Identifiers

PMID35517048
PMCPMC9063564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.