ArticleJournal of radiology case reports2021
Squamous Cell Carcinoma with Clinical Perineural Invasion: Challenges and Review in Single Case Study.
Article in Journal of radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Perineural Invasion of Occult Cutaneous Squamous Cell Carcinoma Mimicking Tolosa-Hunt Syndrome.Neuro-ophthalmology (Aeolus Press) · 2025Article
- A qualitative exploration of the pathway to diagnosis and treatment of cutaneous squamous cell carcinoma of the head and neck with perineural spread.Cancer medicine · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perineural invasion is a rare prognostic finding of squamous cell carcinomas that is associated with a poor prognosis. Early recognition of perineural invasion is imperative to improving treatment and lowering recurrence. Here we report the case of a 77-year-old Caucasian male with a suspicious mass on his forehead. Diagnosis confirms a squamous cell carcinoma with T1-weighted MRI findings significant for perineural invasion of the right supratrochlear nerve based on nerve thickening with loss of fat. Due to his immunocompromised status and the presence of positive margins after wide local excision, the patient is treated with adjuvant external beam radiotherapy of the nerve course. Risks of radiation-induced optic neuropathy should be weighed against recurrence in tumors that invade the trigeminal nerve.
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