Evidence map›Paper›PMID 35516848›Full record

ArticleRSC advances2019

Proteomic analysis reveals the potential neuroprotective effects of tetramethylpyrazine dimer in neuro2a/APPswe cells.

Xiaoyi Lin, Benhong Xu, Zaijun Zhang, Ying Yang, Gongping Liu, Feiqi Zhu, Xiaohu Ren, Jianjun Liu, Shupeng Li, Xianfeng Huang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Xiaoyi LinCollege of Pharmaceutical Engineering and Life Sciences, Changzhou University No. 21, Gehu Middle Road, Wujin District Changzhou China 213000 huangxf@cczu.edu.cn +86 13914325607 +86 13914325607.
Benhong XuKey Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention No. 8, Longyuan Road, Nanshan District Shenzhen China 518055 xifeiyang@gmail.com +86 75525508584 +86 75525601914.
Zaijun ZhangInstitute of New Drug Research and Guangzhou, Key Laboratory of Innovative Chemical Drug Research in Cardio-Cerebrovascular Diseases, Jinan University College of Pharmacy Guangzhou 510632 China.
Ying YangDepartment of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030 China.
Gongping LiuDepartment of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030 China.
Feiqi ZhuCognitive Impairment Ward of Neurology Department, The 3rd Affiliated Hospital of Shenzhen University China.
Xiaohu RenKey Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention No. 8, Longyuan Road, Nanshan District Shenzhen China 518055 xifeiyang@gmail.com +86 75525508584 +86 75525601914.
Jianjun LiuKey Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention No. 8, Longyuan Road, Nanshan District Shenzhen China 518055 xifeiyang@gmail.com +86 75525508584 +86 75525601914.
Shupeng LiState Key Laboratory of Oncogenomic, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Shenzhen 518055 China lisp@pkusz.edu.cn +86 75526032325 +86 75526032325.
Xianfeng HuangCollege of Pharmaceutical Engineering and Life Sciences, Changzhou University No. 21, Gehu Middle Road, Wujin District Changzhou China 213000 huangxf@cczu.edu.cn +86 13914325607 +86 13914325607.
Xifei YangKey Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention No. 8, Longyuan Road, Nanshan District Shenzhen China 518055 xifeiyang@gmail.com +86 75525508584 +86 75525601914.
Shenzhen Center for Disease Control and Prevention · CNHuazhong University of Science and Technology · CN58.com (China) · CNJinan University · CNShenzhen University · CNState Key Laboratory of Oncogene and Related Genes · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by pathological processes, including abnormal amyloid deposits and filament tangles, oxidative stress, neuroinflammation, and neurotrophic insufficiency, leading to chronic and prolonged neuronal loss and cognitive deficits. Tetramethylpyrazine (TMP) is one of the main active components of

Identifiers

PMID35516848
PMCPMC9064821
OpenAlexW2952860102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.