Evidence map›Paper›PMID 35516796›Full record

ArticleFrontiers in neuroscience2022

Atypical Functional Connectivity During Unfamiliar Music Listening in Children With Autism.

Carina Freitas, Benjamin A E Hunt, Simeon M Wong, Leanne Ristic, Susan Fragiadakis, Stephanie Chow, Alana Iaboni, Jessica Brian, Latha Soorya, Joyce L Chen and 5 more

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In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carina FreitasInstitute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Benjamin A E HuntDepartment of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.
Simeon M WongDepartment of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.
Leanne RisticBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Susan FragiadakisBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Stephanie ChowBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Alana IaboniBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Jessica BrianBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Latha SooryaDepartment of Psychiatry, Rush University Medical Center, Chicago, IL, United States.
Joyce L ChenFaculty of Kinesiology and Physical Education and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.
Russell SchacharDepartment of Psychiatry Research, Hospital for Sick Children, Toronto, ON, Canada.
Benjamin T DunkleyDepartment of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada.
Margot J TaylorInstitute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jason P LerchNeuroscience and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Evdokia AnagnostouInstitute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atypical processing of unfamiliar, but less so familiar, stimuli has been described in Autism Spectrum Disorder (ASD), in particular in relation to face processing. We examined the construct of familiarity in ASD using familiar and unfamiliar songs, to investigate the link between familiarity and autism symptoms, such as repetitive behavior. Methods: Forty-eight children, 24 with ASD (21 males, mean age = 9.96 years ± 1.54) and 24 typically developing (TD) controls (21 males, mean age = 10.17 ± 1.90) completed a music familiarity task using individually identified familiar compared to unfamiliar songs, while magnetoencephalography (MEG) was recorded. Each song was presented for 30 s. We used both amplitude envelope correlation (AEC) and the weighted phase lag index (wPLI) to assess functional connectivity between specific regions of interest (ROI) and non-ROI parcels, as well as at the whole brain level, to understand what is preserved and what is impaired in familiar music listening in this population. Results: Increased wPLI synchronization for familiar vs. unfamiliar music was found for typically developing children in the gamma frequency. There were no significant differences within the ASD group for this comparison. During the processing of unfamiliar music, we demonstrated left lateralized increased theta and beta band connectivity in children with ASD compared to controls. An interaction effect found greater alpha band connectivity in the TD group compared to ASD to unfamiliar music only, anchored in the left insula. Conclusion: Our results revealed atypical processing of unfamiliar songs in children with ASD, consistent with previous studies in other modalities reporting that processing novelty is a challenge for ASD. Relatively typical processing of familiar stimuli may represent a strength and may be of interest to strength-based intervention planning.

Indexed as

autism spectrum disorderfamiliarity processingfunctional connectivitymagnetoencephalographymusicneural oscillation

Identifiers

PMID35516796
PMCPMC9063167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.