ArticleEClinicalMedicine2022
Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Childhood modifiable risk factors and later life chronic kidney disease: a systematic review.BMC nephrology · 2023Pooled it
- Subgroup-specific cardiovascular effects of intensive lifestyle intervention: a causal forest analysis in adults with type 2 diabetes and overweight/obesity.Nutrition & diabetes · 2026Trial
- Inflammatory biomarkers are associated with renal injury and partially explain the obesity-renal injury relationship in U.S. adolescents: a cross-sectional NHANES study.BMC nephrology · 2026Article
- Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study.BMC medicine · 2026Article
- Albuminuria as a non-invasive biomarker of endothelial dysfunction in patients with COPD.Scientific reports · 2026Article
- Association between adiposity indices and incident albuminuria: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).BMC nephrology · 2025Article
- Impact of Blood Pressure Across the Life Course on Arterial Stiffness in Midlife: The Mediating Role of Metabolic Factors.MedComm · 2025Article
- Association between long-term changes in obesity-related anthropometric indicators and the risk of type 2 diabetes mellitus in the older population.The Journal of international medical research · 2025Article
- Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness.JACC. Asia · 2025Article
- The Optimal Cut-Off Point of Physical Activity for the Prevention of Childhood Overweight and Obesity.Children (Basel, Switzerland) · 2024Article
- The association of long-term trajectories of BMI, its variability, and metabolic syndrome: a 30-year prospective cohort study.EClinicalMedicine · 2024Article
- Serum cystatin C and cognitive function in midlife: results from the Hanzhong Adolescent Hypertension Study.Frontiers in neurologyArticle
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Authors and funding
29 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Albuminuria is a marker of vascular dysfunction and is associated with chronic renal and cardiovascular diseases. Data on the association between the longitudinal patterns of weight change early in life and albuminuria later in life are limited. We aimed to identify the body mass index (BMI) trajectory across a 30-year span and evaluate its association with middle-age albuminuria. Methods: Of the 4623 participants aged 6-18-year-old recruited by Hanzhong Adolescent Hypertension Study cohort in northern China from March 10, 1987 to June 3, 2017, a total of 1,825 participants followed up with 6 visits over 30 years were enrolled. Group-based trajectory modeling was used to identify distinct BMI trajectories in longitudinal analyses. Albuminuria was defined as a urinary albumin-to-creatinine ratio (uACR) ≥ 30 mg/g. Findings: Three distinct BMI trajectories were identified: low-increasing ( Interpretation: Higher BMI trajectories are associated with higher uACR and an increased risk of albuminuria in middle age, especially in males. Identifying long-term BMI trajectories from an early age may assist in predicting the risk of renal diseases and cardiovascular disease later in life. Funding: This work was supported by the National Natural Science Foundation of China (81600327, 82070437, 81870319, 82070549, and 82170437), Natural Science Basic Research Program of Shaanxi Province (2021JM-257 and 2021JM-588), Institutional Foundation of the First Affiliated Hospital of Xi'an Jiaotong University (2019QN-06 and 2021ZXY-14), the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University of China (XJTU1AF-CRF-2019-004, XJTU1AF2021CRF-021, and XJTU1AFCRF-2017-021), Research Incubation Fund of Xi'an People's Hospital (FZ-61), Grants from the Major Chronic Non-communicable Disease Prevention and Control Research Key Project of the Ministry of Science and Technology of China (2017YFC1307604 and 2016YFC1300104).
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