Evidence map›Paper›PMID 35516214›Full record

ArticleRSC advances2020

Comparative

Neha Maurya, Khalid Imtiyaz, M Moshahid Alam Rizvi, Khaled Mohamed Khedher, Prashant Singh, Rajan Patel

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Neha MauryaBiophysical Chemistry Laboratory, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia New Delhi-110025 India rpatel@jmi.ac.in +91 11 26983409 +91 8860634100.
Khalid ImtiyazDepartment of Biosciences, Jamia Millia Islamia New Delhi-110025 India.
M Moshahid Alam RizviDepartment of Biosciences, Jamia Millia Islamia New Delhi-110025 India.
Khaled Mohamed KhedherDepartment of Civil Engineering, College of Engineering, King Khalid University Abha 6421 Saudi Arabia.ORCID https://orcid.org/0000-0002-4167-1690
Prashant SinghDepartment of Chemistry, ARSD College, University of Delhi New Delhi-110021 India.
Rajan PatelBiophysical Chemistry Laboratory, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia New Delhi-110025 India rpatel@jmi.ac.in +91 11 26983409 +91 8860634100.ORCID https://orcid.org/0000-0002-3811-2898
Jamia Millia Islamia · INTIFR Centre for Interdisciplinary Sciences · INInstitut Supérieur des Études Technologiques de Nabeul · TNUniversity of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin (ART) and its biogenetic precursors artemisinic acid (AA) and dihydroartemisinic acid (DHAA) are important traditional medicinal herb compounds with tumor growth inhibition properties. Herein, we have studied the cytotoxicity of ART, AA, and DHAA on different cancer cell lines (H1299, A431, and HCT 116) and investigated in detail their binding mechanisms with ctDNA by using spectroscopy, cyclic voltammetry, and computational methods. The UV absorbance, cyclic voltammetry, DNA helix melting, competition binding, and circular dichroism studies suggested that the complex formation of ART-ctDNA and AA-ctDNA occurs through groove binding. However, in the case of DHAA-ctDNA interaction, electrostatic interaction plays a major role. The thermodynamic parameters,

Identifiers

PMID35516214
PMCPMC9055135
OpenAlexW3037927923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.