Evidence map›Paper›PMID 35516060›Full record

ArticleRSC advances2020

Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications.

W P T D Perera, Ranga K Dissanayake, U I Ranatunga, N M Hettiarachchi, K D C Perera, Janitha M Unagolla, R T De Silva, L R Pahalagedara

Abstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Review
  3. Metallo-herb complexes as emerging therapeutics: chemistry, synthesis approaches, and pharmacological insights.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Zinc oxide fabricated by rutin as potent anti-leukemia nanostructure.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

W P T D PereraAcademy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.ORCID https://orcid.org/0000-0001-8068-4569
Ranga K DissanayakeSri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.ORCID https://orcid.org/0000-0002-0321-5942
U I RanatungaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo 25 Kynsey Road Colombo 00800 Sri Lanka.
N M HettiarachchiAcademy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.
K D C PereraAcademy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.ORCID https://orcid.org/0000-0001-8859-4189
Janitha M UnagollaBiomedical Engineering Program, Department of Bioengineering, College of Engineering, University of Toledo Toledo OH 43607 USA.
R T De SilvaSri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.
L R PahalagedaraSri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc oxide nanoparticles and curcumin have been shown to be excellent antimicrobial agents and promising anticancer agents, both on their own as well as in combination. Together, they have potential as alternatives/supplements to antibiotics and traditional anticancer drugs. In this study, different morphologies of zinc oxide-grafted curcumin nanocomposites (ZNP-Cs) were synthesized and characterized using SEM, TGA, FTIR, XRD and UV-vis spectrophotometry. Antimicrobial assays were conducted against both Gram negative and Gram-positive bacterial stains. Spherical ZnO-curcumin nanoparticles (SZNP-Cs) and rod-shaped ZnO-curcumin nanoparticles showed the most promising activity against tested bacterial strains. The inhibition zones for these curcumin-loaded ZnO nanocomposites were consistently larger than their bare counterparts or pure curcumin, revealing an additve effect between the ZnO and curcumin components. The potential anticancer activity of the synthesized nanocomposites was studied on the rhabdomyosarcoma RD cell line

Identifiers

PMID35516060
PMCPMC9056367

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.