Evidence map›Paper›PMID 35516041›Full record

ArticleRSC advances2020

Mucus-responsive functionalized emulsions: design, synthesis and study of novel branched polymers as functional emulsifiers.

Stephanie E Edwards, Sean Flynn, James J Hobson, Pierre Chambon, Helen Cauldbeck, Steve P Rannard

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Functionalization of Emulsion Interfaces: Surface Chemistry Made Liquid.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Stephanie E EdwardsDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.
Sean FlynnDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.
James J HobsonDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.
Pierre ChambonDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.
Helen CauldbeckDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.
Steve P RannardDepartment of Chemistry, University of Liverpool Crown Street L69 7ZD UK srannard@liv.ac.uk.ORCID https://orcid.org/0000-0002-6946-1097
University of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucus lines the moist cavities throughout the body, acting as barrier by protecting the underlying cells against the external environment, but it also hinders the permeation of drugs and drug delivery systems. As the rate of diffusion is low, the development of a system which could increase retention time at the mucosal surface would prove beneficial. Here, we have designed a range of branched copolymers to act as functional mucus-responsive oil-in-water emulsifiers comprising the hydrophilic monomer oligo(ethylene glycol) methacrylate and a hydrophobic dodecyl initiator. The study aimed to investigate the importance of chain end functionality on successful emulsion formation, by systematically replacing a fraction of the hydrophobic chain ends with a secondary poly(ethylene glycol) based hydrophilic initiator in a mixed-initiation strategy; a decrease of up to 75 mole percent of hydrophobic chain ends within the branched polymer emulsifiers was shown to maintain comparative emulsion stability. These redundant chain ends allowed for functionality to be incorporated into the polymers

Identifiers

PMID35516041
PMCPMC9056332
OpenAlexW3078135516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.