Evidence map›Paper›PMID 35515975›Full record

ReviewSisli Etfal Hastanesi tip bulteni2022

Pharmacotherapy of Painful Diabetic Neuropathy: A Clinical Update.

Cornelius Fernandez James, Shiva Tripathi, Kyriaki Karampatou, Divya V Gladston, Joseph M Pappachan

Open access · hybridAbstract readReview
In one paragraph

Review in Sisli Etfal Hastanesi tip bulteni, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cornelius Fernandez JamesDepartment of Endocrinology & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, United Kingdom.ORCID https://orcid.org/0000-0002-1171-5525
Shiva TripathiDepartment of Anaesthesia & Pain Management, Lancashire Teaching Hospitals NHS Trust, United Kingdom.ORCID https://orcid.org/0000-0002-9489-1910
Kyriaki KarampatouDepartment of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust, United Kingdom.ORCID https://orcid.org/0000-0001-9491-5479
Divya V GladstonDepartment of Anaesthesiology, Regional Cancer Centre, Thiruvananthapuram, India.ORCID https://orcid.org/0000-0003-3770-1794
Joseph M PappachanDepartment of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust, United Kingdom; The University of Manchester, Manchester, UK; Manchester Metropolitan University, Manchester, UK.ORCID https://orcid.org/0000-0003-0886-5255
United Lincolnshire Hospitals NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of diabetes mellitus (DM) leads on to an increase in chronic diabetic complications. Diabetic peripheral neuropathies (DPNs) are common chronic complications of diabetes. Distal symmetric polyneuropathy is the most prevalent form. Most patients with DPN will remain pain-free; however, painful DPN (PDPN) occurs in 6-34% of all DM patients and is associated with reduced health-related-quality-of-life and substantial economic burden. Symptomatic treatment of PDPN and diabetic autonomic neuropathy is the key treatment goals. Using certain patient related characteristics, subjects with PDPN can be stratified and assigned targeted therapies to produce better pain outcomes. The aim of this review is to discuss the various pathogenetic mechanisms of DPN with special reference to the mechanisms leading to PDPN and the various pharmacological and non-pharmacological therapies available for its management. Recommended pharmacological therapies include anticonvulsants, antidepressants, opioid analgesics, and topical medications.

Indexed as

Diabetes mellitusDiabetic peripheral neuropathyGabapentinoidsOpioidsPainful diabetic peripheral neuropathy

Identifiers

PMID35515975
PMCPMC9040305
OpenAlexW4205203503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.