Evidence map›Paper›PMID 35515832›Full record

ArticleRSC advances2019

Forsythiaside inhibited titanium particle-induced inflammation

Kaihang Xu, Rongzhi He, Yuan Zhang, Sheng Qin, Guangchao Wang, Qiang Wei, Hao Zhang, Fang Ji

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Nutrients · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kaihang XuDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.ORCID https://orcid.org/0000-0001-5064-5593
Rongzhi HeDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.
Yuan ZhangDepartment of Ophthalmology, Changhai Hospital Affiliated to the Navy Military Medical University Shanghai People's Republic of China.
Sheng QinDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.
Guangchao WangDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.ORCID https://orcid.org/0000-0003-4285-7144
Qiang WeiDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.
Hao ZhangDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.
Fang JiDepartment of Orthopedics, Changhai Hospital Affiliated to the Navy Military Medical University, Changhai Hospital, The Navy Military Medical University No. 168 Changhai Road Shanghai 200433 People's Republic of China zhanghsmmu@126.com doctorjif@126.com +86-021-31161682 +86-021-31161696 +86-021-31161682 +86-021-31161696.
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wear particle-induced periprosthetic osteolysis is the primary complication of the total joint replacement; however, no conservative treatment except for reversal surgery is available for this disease. During the past decade, Chinese herbal medicines have been widely investigated to inhibit osteoclast differentiation, which may exhibit the potential to treat wear particle-induced periprosthetic osteolysis. The present study was aimed at the investigation of the effects of forsythiaside on osteocytes. The current data revealed that the forsythiaside treatment notably inhibited the titanium (Ti) particle-induced inflammation through impaired NF-κB signaling, thereby inhibiting TNF-α and IL-1β. In addition, the

Identifiers

PMID35515832
PMCPMC9063541
OpenAlexW2942147848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.