ArticleRSC advances2020
Preparing 3D-printable silk fibroin hydrogels with robustness by a two-step crosslinking method.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- The structure and extraction of silk fibroin and its applications in fruit and vegetable preservation: a review.Food chemistry: X · 2026Review
- Structurally and functionally optimized silk fibroin-alginate-based biomimetic scaffolds reinforced with nanobioceramics for bone tissue engineering applications.Journal of nanobiotechnology · 2025Article
- Degumming Time Governs Self-Assembled Silk Fibroin Hydrogel Properties through Molecular Weight and Amino Acid Composition.Biomacromolecules · 2025Article
- Light from Afield: Fast, High-Resolution, and Layer-Free Deep Vat 3D Printing.Chemical reviews · 2024Review
- Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting.Materials today. Bio · 2024Article
- Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications.Biomacromolecules · 2023Review
- Photocrosslinkable natural polymers in tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Application Prospect and Preliminary Exploration of GelMA in Corneal Stroma Regeneration.Polymers · 2022Review
- 3D Printed Hydrogels for Ocular Wound Healing.Biomedicines · 2022Review
- Highly stretchable, self-healing and conductive silk fibroin-based double network gelsRSC advances · 2022Article
- In Situ 3D Printing: Opportunities with Silk Inks.Trends in biotechnology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerated silk fibroin (RSF) features excellent biocompatibility and high-strength mechanical properties. However, traditional RSF-based materials can hardly be applied in 3D printing, which has shown great potential in producing artificial implants. In this work, we report a 3D printable RSF hydrogel formed by a weak, chemically crosslinked network. After the 3D printing process, the mechanical properties of the above hydrogel can be remarkably improved by a ripening process. The maximum compressive modulus of this RSF hydrogel is 2.5 MPa, reaching the same order of magnitude as natural elastomers such as cartilage. The mechanical properties of this hydrogel are superior to most RSF-based 3D printed hydrogels. The investigation of gelation mechanism reveals that the chemically crosslinked network can constrain the growth of β-sheet structures of RSF to form a dense and uniform physical network. Such a physically crosslinked network endows the high strength and good resilience of RSF hydrogels. With both good biocompatibility and mechanical properties, this double-network hydrogel has potential in producing 3D printed scaffolds for tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.