Evidence map›Paper›PMID 35515778›Full record

ReviewRSC advances2020

A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems.

Yongtao Duan, Abhishek Dhar, Chetan Patel, Mehul Khimani, Swarnali Neogi, Prolay Sharma, Nadavala Siva Kumar, Rohit L Vekariya

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 1 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 1 synthesis or guideline pooled it, 560 citations in OpenAlex.

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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 6 countries.

Yongtao DuanHenan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University Henan 450018 China.
Abhishek DharDepartment of Instrumentation & Electronics Engineering, Jadavpur University Kolkata 700106 India.
Chetan PatelSchool of Sciences, P P Savani University NH-8, GETCO, Near Biltech, Village: Dhamdod, Kosamba, Dist. Surat 394125 Gujarat India.
Mehul KhimaniSchool of Sciences, P P Savani University NH-8, GETCO, Near Biltech, Village: Dhamdod, Kosamba, Dist. Surat 394125 Gujarat India.
Swarnali NeogiDepartment of Instrumentation & Electronics Engineering, Jadavpur University Kolkata 700106 India.
Prolay SharmaDepartment of Instrumentation & Electronics Engineering, Jadavpur University Kolkata 700106 India.
Nadavala Siva KumarDepartment of Chemical Engineering, King Saud University P.O. Box 800 Riyadh 11421 Saudi Arabia.ORCID https://orcid.org/0000-0003-3210-8254
Rohit L VekariyaDepartment for Management of Science and Technology Development, Ton Duc Thang University Ho Chi Minh City Vietnam.ORCID https://orcid.org/0000-0001-6195-114X
Saint Petersburg State University of Aerospace and Instrumentation · RUSardar Vallabhbhai National Institute of Technology Surat · INKing Saud University · SATon Duc Thang University · VNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.

Identifiers

PMID35515778
PMCPMC9055574
OpenAlexW3043255293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.