Evidence map›Paper›PMID 35515616›Full record

ArticleRSC advances2020

One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups.

Stéphane Duflocq, Jingjing Zhou, Florent Huguenot, Michel Vidal, Wang-Qing Liu

Abstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stéphane DuflocqUniversité de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France wangqing.liu@parisdescartes.fr.ORCID https://orcid.org/0000-0002-3073-1643
Jingjing ZhouUniversité de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France wangqing.liu@parisdescartes.fr.
Florent HuguenotUniversité de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France wangqing.liu@parisdescartes.fr.ORCID https://orcid.org/0000-0001-8400-0857
Michel VidalUniversité de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France wangqing.liu@parisdescartes.fr.
Wang-Qing LiuUniversité de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France wangqing.liu@parisdescartes.fr.ORCID https://orcid.org/0000-0003-0511-3058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One-pot oxime ligation under mild conditions using Pd(ii) as a shared catalyst from an aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two complementary metal-free protocols using unmasked Aoa-peptide are also described. Acetoxime-peptide can proceed to the desired oxime through an additional transoximation step.

Identifiers

PMID35515616
PMCPMC9053634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.