Evidence map›Paper›PMID 35515436›Full record

ArticleRSC advances2020

Lipofection with estrone-based luminophores featuring aggregation-induced emission properties.

Steffen Riebe, Alexander Zimmermann, Johannes Koch, Cecilia Vallet, Shirley K Knauer, Andrea Sowa, Christoph Wölper, Jens Voskuhl

Abstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Luminescent Amphiphilic Aminoglycoside Probes to Study Transfection.Chembiochem : a European journal of chemical biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Steffen RiebeInstitute for Organic Chemistry and CENIDE, University of Duisburg-Essen Universitätsstrasse 7 45141 Essen Germany jens.voskuhl@uni-due.de.
Alexander ZimmermannInstitute for Organic Chemistry and CENIDE, University of Duisburg-Essen Universitätsstrasse 7 45141 Essen Germany jens.voskuhl@uni-due.de.
Johannes KochICCE, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen Universitätsstrasse 2 45141 Essen Germany.
Cecilia ValletDepartment of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen 45117 Essen Germany.
Shirley K KnauerDepartment of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg-Essen 45117 Essen Germany.
Andrea SowaInstitute for Organic Chemistry and CENIDE, University of Duisburg-Essen Universitätsstrasse 7 45141 Essen Germany jens.voskuhl@uni-due.de.
Christoph WölperInstitute for Inorganic Chemistry and Center for NanoIntegration (CENIDE), University of Duisburg-Essen Universitätsstrasse 5-7 45117 Essen Germany.
Jens VoskuhlInstitute for Organic Chemistry and CENIDE, University of Duisburg-Essen Universitätsstrasse 7 45141 Essen Germany jens.voskuhl@uni-due.de.ORCID https://orcid.org/0000-0002-9612-2306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this communication we present the use of a novel class of luminophores with aggregation-induced emission (AIE) properties based on the steroid estrone. These molecules were equipped with cationic residues yielding amphiphiles suitable for lipofection. To this end, self-assembled luminescent structures were formed in aqueous media and mixed with a red-fluorescent protein expressing plasmid, yielding lipoplexes with increased emission intensity. These luminescent lipoplexes were able to efficiently transfect HeLa and HEK 293T cells and were able to be tracked due to the aggregation induced-emission properties.

Identifiers

PMID35515436
PMCPMC9054052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.