Evidence map›Paper›PMID 35515361›Full record

ArticleRSC advances2020

Design and fabrication of a microfluidic chip to detect tumor markers.

Cuimin Sun, Hui You, Nailong Gao, Jianguo Chang, Qingxue Gao, Yang Xie, Yao Xie, Ronald X Xu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Cuimin SunDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.ORCID 0000-0003-4174-1094
Hui YouDepartment of Mechanical Engineering, Guangxi University Nanning Guangxi 530004 PR China hyou@gxu.edu.cn.
Nailong GaoDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
Jianguo ChangDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
Qingxue GaoDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
Yang XieDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
Yao XieDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
Ronald X XuDepartment of Mechanical Engineering and Precision Machinery, University of Science and Technology of China Hefei Anhui 230001 PR China.
University of Science and Technology of China · CNGuangxi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A microfluidic chip based on capillary infiltration was designed to detect tumor markers. Serum samples flowed along a microchannel that used capillary force to drive sample injection, biochemical reactions and waste liquid collection. This permitted us to realize rapid qualitative detection of tumor markers and other biological molecules. The chip integrated a number of microfluidic functions including blood plasma separation, microvalve operation, and antibody immobilization. Using antigen-antibody reaction principles, the chip provided highly selective and sensitive detection of markers. Combining a microfluidic chip with immunoassays not only improved the antigen-antibody reaction speed, but also reduced the consumption of samples and reagents. The experimental results showed that the chip can achieve separation of trace whole blood, control of sample flow rate, and detection of alpha fetoprotein, thus providing preliminary verification of its feasibility and potential for clinical use. In summary, in this paper a cheap, mass-produced, and portable microfluidic chip for cancer detection, which has good prospects for practical use during disease diagnosis and screening is reported.

Identifiers

PMID35515361
PMCPMC9057392
OpenAlexW3096456971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.