Evidence map›Paper›PMID 35514974›Full record

ArticleFrontiers in immunology2022

Long-Term, CD4

Sebastian Wirsching, Laura Harder, Markus Heymanns, Britta Gröndahl, Katja Hilbert, Frank Kowalzik, Claudius Meyer, Stephan Gehring

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. Review
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  11. Persistent humoral and CD4Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sebastian WirschingChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Laura HarderChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Markus HeymannsChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Britta GröndahlChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Katja HilbertChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Frank KowalzikChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Claudius MeyerChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Stephan GehringChildren's Hospital, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Johannes Gutenberg University Mainz · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first cases of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported by Chinese authorities at the end of 2019. The disease spread quickly and was declared a global pandemic shortly thereafter. To respond effectively to infection and prevent viral spread, it is important to delineate the factors that affect protective immunity. Herein, a cohort of convalescent healthcare workers was recruited and their immune responses were studied over a period of 3 to 9 months following the onset of symptoms. A cross-reactive T cell response to SARS-CoV-2 and endemic coronaviruses, i.e., OC43 and NL63, was demonstrated in the infected, convalescent cohort, as well as a cohort composed of unexposed individuals. The convalescent cohort, however, displayed an increased number of SARS-CoV-2-specific CD4

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralCD4-Positive T-LymphocytesHumansMemory T CellsSpike Glycoprotein, CoronavirusAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2cross-reactivityHCoVlong-term memorySARS-CoV-2T cell immunity

Identifiers

PMID35514974
PMCPMC9065554
OpenAlexW4224252591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.