ReviewRSC advances2020
Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.
Review in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview.ChemMedChem · 2026Review
- Multicomponent Reactions for the Synthesis of Oxazepines.Topics in current chemistry (Cham) · 2026Review
- Generating multimillion chemical space based on the Ugi four-center three-component reaction with oxocarboxylic acids.Molecular diversity · 2026Article
- Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.Organic & biomolecular chemistry · 2026Article
- Ugi and Groebke-Blackburn-Bienaymé Reactions in Medicinal Chemistry: An Outlook on New Bioactive Compounds.ACS omega · 2025Review
- Photoexcited Palladium Complex-Catalyzed Isocyanide Insertion into Inactivated Alkyl Iodides.Molecules (Basel, Switzerland) · 2025Article
- Unlocking Enol-Ugi-Derived Conformationally Restricted Peptidomimetic Motifs.The Journal of organic chemistry · 2025Article
- Covalent Proximity Inducers.Chemical reviews · 2025Review
- New tandem Ugi/intramolecular Diels-Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives.Beilstein journal of organic chemistry · 2025Article
- CspACS catalysis · 2024Article
- Versatile, Modular, and General Strategy for the Synthesis of α-Amino Carbonyls.Journal of the American Chemical Society · 2024Article
- Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024Review
- Non-symmetric stapling of native peptides.Nature reviews. Chemistry · 2024Review
- Diastereoselective ZnClMolecules (Basel, Switzerland) · 2024Article
- Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines.Molecular diversity · 2024Article
- Curation and cheminformatics analysis of a Ugi-reaction derived library (URDL) of synthetically tractable small molecules for virtual screening application.Molecular diversity · 2024Article
- Review
- A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.Molecules (Basel, Switzerland) · 2024Article
- Ni-Fe bimetallic catalysts with high dispersion supported by SBA-15 evaluated for the selective oxidation of benzyl alcohol to benzaldehyde.RSC advances · 2024Article
- The Ugi4CR as effective tool to access promising anticancer isatin-based α-acetamide carboxamide oxindole hybrids.Beilstein journal of organic chemistry · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two starting materials couple with each other to form multi-functionalized compounds in a one-pot process, the so-called "tandem", "domino" or "cascade" reaction, or utilizing an additional step without changing the solvent, the so-called a sequential-addition procedure, to limit the number of synthetic steps, while increasing the complexity and the molecular diversity, which are highly step-economical reactions. The Ugi reaction, one of the most common multicomponent reactions, has recently fascinated chemists with the high diversity brought by its four- or three-component-based isonitrile. The Ugi reaction has been introduced in organic synthesis as a novel, efficient and useful tool for the preparation of libraries of multifunctional peptides, natural products, and heterocyclic compounds with stereochemistry control. In this review, we highlight the recent advances of the Ugi reaction in the last two decades from 2000-2019, mainly in the synthesis of linear or cyclic peptides, heterocyclic compounds with versatile ring sizes, and natural products, as well as the enantioselective Ugi reactions. Meanwhile, the applications of these compounds in pharmaceutical trials are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.