Evidence map›Paper›PMID 35514776›Full record

ArticlePulmonary circulation2022

Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity.

Melanie K Nies, Jun Yang, Megan Griffiths, Rachel Damico, Jie Zhu, Dhananjay Vaydia, Zongming Fu, Stephanie Brandal, Eric D Austin, Dunbar D Ivy and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Melanie K NiesDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Jun YangDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.ORCID 0000-0001-9273-4578
Megan GriffithsDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Rachel DamicoDepartment of Medicine, Division of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Jie ZhuDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Dhananjay VaydiaDepartment of Medicine, Division of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Zongming FuDepartment of Pediatrics, Division of Hematology Johns Hopkins University Baltimore Maryland USA.
Stephanie BrandalDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Eric D AustinDepartment of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine Vanderbilt University Nashville Tennessee USA.
Dunbar D IvyDepartment of Pediatric Cardiology Children's Hospital Colorado Aurora Colorado USA.
Paul M HassounDepartment of Medicine, Division of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore Maryland USA.
Jennifer E Van EykDepartment of Internal Medicine, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Allen D EverettDepartment of Pediatrics, Division of Cardiology Johns Hopkins University Baltimore Maryland USA.
Johns Hopkins University · USCedars-Sinai Medical Center · USChildren's Hospital Colorado · USVanderbilt University · US

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Clinical and mechanistic role of HDGF in pulmonary hypertensionR01HL135114 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D · 2017 to 2020
$2.9M
Role of IGF axis in pulmonary hypertensionR01HL150070 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, YANG, JUN · 2020 to 2023
$2.8M
Circulating biomarkers of IPAH.R03HL110830 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D · 2011 to 2012
$162k
NHLBI NIH HHS R01 HL135114NHLBI NIH HHS R01 HL150070NHLBI NIH HHS R03 HL110830NHLBI NIH HHS R24 HL123767NICHD NIH HHS K12 HD000850
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by sustained elevations of pulmonary artery pressure. To date, we lack circulating, diagnostic, and prognostic markers that correlate to clinical and functional parameters. In this study, we performed mass spectrometry-based proteomics analysis to identify circulating biomarkers of PAH. Plasma samples from patients with idiopathic pulmonary arterial hypertension (IPAH,

Indexed as

biomarkerIGF binding proteinproteomicspulmonary hypertension

Identifiers

PMID35514776
PMCPMC9063962
OpenAlexW4210508821

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.