Evidence map›Paper›PMID 35514396›Full record

ArticleRSC advances2020

Study on mechanism of elemene reversing tumor multidrug resistance based on luminescence pharmacokinetics in tumor cells

Liying Chen, Zhi Chen, Shuang Zheng, Luhui Fan, Lixin Zhu, Jiandong Yu, Chaoyuan Tang, Qi Liu, Yang Xiong

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. How to Select Firefly Luciferin Analogues for In Vivo Imaging.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Liying ChenDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.ORCID https://orcid.org/0000-0003-0990-7648
Zhi ChenDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Shuang ZhengDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Luhui FanDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Lixin ZhuDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Jiandong YuDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Chaoyuan TangDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Qi LiuDepartment of Dermatology, Johns Hopkins University School of Medicine Baltimore MD 21231 USA.
Yang XiongDepartment of Pharmaceutical Science, College of Pharmaceutical Science, Zhejiang Chinese Medical University Hangzhou 311400 Zhejiang China.
Zhejiang Chinese Medical University · CNJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While elemene (ELE) can reverse tumor multidrug resistance (MDR), the mechanisms for ELE reversing MDR remain unclear. Numerous studies have suggested that the efflux functionality of ATP-binding cassette (ABC) transporters, not their quantity, is more relevant to tumor MDR. However, no appropriate methods exist for real-time detection of the intracellular drug efflux caused by ABC transporters

Identifiers

PMID35514396
PMCPMC9056898
OpenAlexW3087104560

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.