Evidence map›Paper›PMID 35514214›Full record

ArticleCephalalgia : an international journal of headache2022

Validation of diagnostic ICHD-3 criteria for menstrual migraine.

Iris E Verhagen, Hermes Aj Spaink, Britt Wh van der Arend, Daphne S van Casteren, Antoinette MaassenVanDenBrink, Gisela M Terwindt

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Article in Cephalalgia : an international journal of headache, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

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15citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Iris E VerhagenDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9509-7233
Hermes Aj SpainkDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Britt Wh van der ArendDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Daphne S van CasterenDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Antoinette MaassenVanDenBrinkDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess validity of ICHD-3 diagnostic criteria for menstrual migraine.

methodsWe performed a longitudinal E-diary study in premenopausal women with migraine. Menstrual migraine diagnosis was self-reported at baseline, and verified according to diary based ICHD-3 criteria and a previous proposed statistical model. Validity of self-reported menstrual migraine was compared to diary based diagnosis and statistical diagnosis. Test-retest reliability and concordance between both methods were determined. Clinical characteristics of perimenstrual and non-perimenstrual migraine attacks were compared in women with and without menstrual migraine.

resultsWe included 607 women. Both women who did and women who did not self-report to suffer from menstrual migraine fulfilled ICHD-3 criteria in the E-diary in two thirds of cases. Pure menstrual migraine was extremely rare (<1%). Concordance between statistical and diary based diagnosis was minimal (κ = 0.28, 95% CI:0.23-0.33). Women diagnosed with menstrual migraine showed 37-50% longer attack duration and increased triptan intake (OR 1.19-1.22, p < 0.001) during perimenstrual attacks.

conclusionSelf-reported menstrual migraine diagnosis has extremely poor accuracy. Two thirds of women suffer from menstrual migraine, independent of self-reports. Pure menstrual migraine is rare. Women with menstrual migraine have longer attack duration and increased triptan intake during perimenstrual attacks, in contrast to women without menstrual migraine. Prospective headache (E-)diaries are required for a menstrual migraine diagnosis, also in clinical practice.

Indexed as

Migraine DisordersPremenstrual SyndromeFemaleHumansProspective StudiesReproducibility of ResultsTryptaminesTryptaminesE-diaryHeadache classificationICHD-3menstrual migrainewomen

Identifiers

PMID35514214
PMCPMC9535967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.