Evidence map›Paper›PMID 35514163›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase.

Supreet Kaur, Nicholas S Nieto, Peter McDonald, Josh R Beck, Richard B Honzatko, Anuradha Roy, Scott W Nelson

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024
    Review
  5. Article
  6. Transient State Kinetics ofBiochemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Supreet KaurDepartment of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Nicholas S NietoDepartment of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Peter McDonaldHigh Throughput Screening Laboratory, University of Kansas, Lawrence, KS, USA.
Josh R BeckDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Richard B HonzatkoDepartment of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Anuradha RoyHigh Throughput Screening Laboratory, University of Kansas, Lawrence, KS, USA.
Scott W NelsonDepartment of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
Iowa State University · USHigh Throughput Biology (United States) · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Targeting Plasmodium apicoplast DNA replication for the treatment and prevention of malariaR21AI127622 · NIAID · IOWA STATE UNIVERSITY · PI NELSON, SCOTT W. · 2017 to 2018
$413k
NCI NIH HHS P30 CA168524NIAID NIH HHS R21 AI127622NIGMS NIH HHS P20 GM113117
6 · The paper itself

Abstract

Malaria is caused by infection with protozoan parasites of the

Indexed as

AntimalarialsApicoplastsMalariaDNADNA-Directed DNA PolymeraseHumansPlasmodium falciparumProtozoan ProteinsAntimalarialsDNADNA-Directed DNA PolymeraseProtozoan ProteinsapicoplastDNA polymerasehigh-throughput screeningMalaria

Identifiers

PMID35514163
PMCPMC9090415
OpenAlexW4229000482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.