Evidence map›Paper›PMID 35513882›Full record

Trial reportBMC psychiatry2022

Effect of behavioral activation on time and frequency domain heart rate variability in older adults with subthreshold depression: a cluster randomized controlled trial in Thailand.

Wanvisa Saisanan Na Ayudhaya, Nuttorn Pityaratstian, Wichai Eungpinichpong, Thanapoom Rattananupong, Parinya Kitidumrongsuk, Sriprapa Loonlawong, Wiroj Jiamjarasrangsi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Wanvisa Saisanan Na AyudhayaDepartment of Community Public Health, School of Public Health, Walailak University, Nakhon Si Thammarat, Thailand.
Nuttorn PityaratstianDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Wichai EungpinichpongResearch Center in Back, Neck, and Other Joint Pain and Human Performance, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Thanapoom RattananupongDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Parinya KitidumrongsukDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sriprapa LoonlawongRegional Health Promotion Center 9 Nakhon Ratchasima, Department of Health, Nakhon Ratchasima, Thailand.
Wiroj JiamjarasrangsiDepartment of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wjiamja@gmail.com.
Chulalongkorn University · THKhon Kaen University · THNakhon Ratchasima Rajabhat University · THWalailak University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased prevalence of depression highlights the need for effective interventions. Behavioral activation (BA), which can easily be adapted for non-clinical populations, has been the recommended treatment for depression. It is based on a model of psychopathology explaining that losses or chronically low levels of positive reinforcement yield behavioral and emotional changes in depression and that encouraging individuals to increase their engagement in reinforcing activities can improve their mood and enhance their valuable life experiences. Heart rate variability (HRV) provides indices of autonomic function related to depression, but only a few studies have investigated the effect of BA on HRV, particularly among older adults with subthreshold depression. Accordingly, we aimed to investigate the effect of BA on HRV in older adults with subthreshold depression.

methodsWe conducted a 9-month cluster randomized controlled trial in two Health Promoting Hospitals (HPHs). Eighty-two participants were randomized into either intervention (BA with usual care) or control (usual care only) groups, with 41 participants per group. Daily step count was collected weekly during the 12-week BA intervention period, while HRV parameters, including the Standard Deviation of the Normal-to-Normal interval (SDNN), High Frequency (lnHF), Low Frequency (LF), and Low Frequency/High Frequency ratio (LF/HF), were examined at 0, 3, 6 and 9 months. Generalized Estimating Equations (GEEs) were used in the data analysis.

resultsOver nine months, the intervention and control groups differed significantly in the unadjusted mean change of HRV, SDNN [7.59 ms (95% CI: 1.67, 13.50)], lnHF [0.44 ms

conclusionOur results suggest that BA may have a therapeutic effect on depression symptoms of older adults with subthreshold depression via improved HRV.

trial registrationTCTR20211019003 , thaiclinicaltrials.org, retrospectively registered on 19 October 2021.

Indexed as

Behavior TherapyDepressionAgedHeart RateHumansThailandBehavioral ActivationCluster randomized controlled trialHeart Rate VariabilityOlder AdultsSubthreshold DepressionTime and Frequency Domain

Identifiers

PMID35513882
PMCPMC9069783
OpenAlexW4228996770

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.