ArticleBMC pediatrics2022
Impact of early term and late preterm birth on infants' neurodevelopment: evidence from a cohort study in Wuhan, China.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Cognitive and academic outcomes of large-for-gestational-age babies born at early term: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Formula with large, milk phospholipid-coated lipid droplets in late-moderate preterm infants: a double-blind RCT.Pediatric research · 2025Trial
- Sex Differences in Combined Effects of Maternal Pre-Pregnancy BMI and OGTT Response Patterns on Early Neurodevelopment in Offspring: A Cohort Study.Journal of diabetes · 2026Article
- Article
- Temporal dynamics of gut microbiota and virome in preterm infants: insights from longitudinal metagenomic analysis.Frontiers in cellular and infection microbiology · 2026Article
- Neurodevelopmental risks of late-preterm and early-term births: a population-based study from Finland.BMJ public health · 2026Article
- Article
- Long-Term Neurodevelopmental Outcomes of Late Preterm Children: A Pilot Study on the Role of Early Nutrition.Nutrients · 2025Article
- The Feasibility of the Arabic Version of Ages and Stages Questionnaire 3 to Identify Preterm Infants at Risk of Developmental Delays in Saudi Arabia.Pediatric reports · 2025Article
- Short- and Long-Term Consequences of Late-Preterm and Early-Term Birth.Children (Basel, Switzerland) · 2025Review
- Association of prenatal trajectories of depressive and anxiety symptoms with neurodevelopment of children aged 0-24 months: A prospective study.Frontiers in psychiatry · 2025Article
- Long-term health outcomes of preterm birth: a narrative review.Frontiers in pediatrics · 2025Review
- Developmental Trajectories and Differences in Functional Brain Network Properties of Preterm and At-Term Neonates.Human brain mapping · 2025Article
- Temporal complexity of the BOLD-signal in preterm versus term infants.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Gestational Age and Neurodevelopmental Delay in Term Births at 6 and 12 Months: The Japan Environment and Children's Study (JECS).Maternal and child health journal · 2024Article
- Differences in the amplitude of low-frequency fluctuations of spontaneous brain activity between preterm and term infants.Frontiers in neurology · 2024Article
- Article
- [Research hotspots in post-discharge follow-up management of preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Associations of preterm and early-term birth with suspected developmental coordination disorder: a national retrospective cohort study in children aged 3-10 years.World journal of pediatrics : WJP · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidences of early term and late preterm birth have increased worldwide during recent years. However, there is a lack of prospective study about the influence of early term and late preterm birth on infants' neurodevelopment, especially at the early stage. Therefore, we conducted this cohort study to investigate the impact of early term and late preterm birth on infants' neurodevelopment within 6 months.
methodsThis cohort study was conducted in Wuhan, China, between October 2012 and September 2013. A total of 4243 singleton infants born within 34-41 weeks of gestation at Wuhan Children's Hospital were included. The Gesell Developmental Scale (GDS) was utilized to evaluate the neurodevelopment of infants.
resultsAmong the 4243 included participants, 155 (3.65%) were late preterm infants, 1288 (30.36%) were early term infants, and 2800 (65.99%) were full term infants. After adjusted for potential confounders, significant negative relationship was shown between late preterm birth and development quotient (DQ) in all domains of neurodevelopment: gross motor (β = - 17.42, 95% CI: - 21.15 to - 13.69), fine motor (β = - 23.61, 95% CI: - 28.52 to - 18.69), adaptability (β = - 10.10, 95% CI: - 13.82 to - 6.38), language (β = - 6.28, 95% CI: - 9.82 to - 2.74) and social behavior (β = - 5.99, 95% CI: - 9.59 to - 2.39). There was a significant negative trend for early term birth in DQ of fine motor (β = - 2.01, 95% CI: - 3.93 to - 0.09). Late preterm infants had a significantly elevated risk of neurodevelopmental delay in domains of gross motor (adjusted OR = 3.82, 95% CI: 2.67 to 5.46), fine motor (adjusted OR = 3.51, 95% CI: 2.47 to 5.01), and adaptability (adjusted OR = 1.60, 95% CI: 1.12 to 2.29), whereas early term birth was significantly associated with neurodevelopmental delay of fine motor (adjusted OR = 1.22, 95% CI: 1.05 to 1.42).
conclusionsThis study suggested that late preterm birth mainly elevated the risk of neurodevelopmental delay of gross motor, fine motor, and adaptability, whereas early term birth was associated with the developmental delay of fine motor within 6 months. Further research is needed to determine the effectiveness and necessity of the interventions at the early stage for early term and late preterm infants who had suspected neurodevelopmental delay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.