Evidence map›Paper›PMID 35513725›Full record

ArticleNature genetics2022

Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii.

Friedrich Fauser, Josep Vilarrasa-Blasi, Masayuki Onishi, Silvia Ramundo, Weronika Patena, Matthew Millican, Jacqueline Osaki, Charlotte Philp, Matthew Nemeth, Patrice A Salomé and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 91 citations in OpenAlex.

  1. Functional Genomics Screening inEnvironmental science & technology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Friedrich Fauser *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Josep Vilarrasa-Blasi *Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Masayuki OnishiDepartment of Biology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9799-4501
Silvia RamundoDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Weronika PatenaDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Matthew MillicanDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Jacqueline OsakiDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Charlotte PhilpDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Matthew NemethDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Patrice A SaloméDepartment of Chemistry and Biochemistry and Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4452-9064
Xiaobo LiDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-3951-9646
Setsuko WakaoDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Rick G KimDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Yuval KayeDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Arthur R GrossmanDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Krishna K NiyogiDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-7229-2071
Sabeeha S MerchantDepartment of Chemistry and Biochemistry and Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA, USA.
Sean R CutlerDepartment of Botany and Plant Sciences, University of California, Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0002-8593-0885
Peter WalterDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6849-708X
José R DinnenyDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA. dinneny@stanford.edu.ORCID http://orcid.org/0000-0002-3998-724X
Martin C JonikasDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. mjonikas@princeton.edu.ORCID http://orcid.org/0000-0002-9519-6055
Robert E JinkersonDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA. robert.jinkerson@ucr.edu.ORCID http://orcid.org/0000-0001-9399-1613
Carnegie Institution for Science · USUniversity of California, Los Angeles · USUniversity of California, Riverside · USUniversity of California, San Francisco · USDuke University · USHoward Hughes Medical Institute · USLawrence Berkeley National Laboratory · US

Funding

Transforming our understanding of eukaryotic gene functions through chemical genetics in the green alga Chlamydomonas reinhardtiiDP2GM119137 · NIGMS · PRINCETON UNIVERSITY · PI JONIKAS, MARTIN CASIMIR · 2015 to 2015
$2.4M
Howard Hughes Medical Institute 55108535NIGMS NIH HHS DP2 GM119137
6 · The paper itself

Abstract

Most genes in photosynthetic organisms remain functionally uncharacterized. Here, using a barcoded mutant library of the model eukaryotic alga Chlamydomonas reinhardtii, we determined the phenotypes of more than 58,000 mutants under more than 121 different environmental growth conditions and chemical treatments. A total of 59% of genes are represented by at least one mutant that showed a phenotype, providing clues to the functions of thousands of genes. Mutant phenotypic profiles place uncharacterized genes into functional pathways such as DNA repair, photosynthesis, the CO

Indexed as

ArabidopsisChlamydomonas reinhardtiiEukaryotaPhenotypePhotosynthesis

Identifiers

PMID35513725
PMCPMC9110296
OpenAlexW4229010849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.