Evidence map›Paper›PMID 35513720›Full record

Trial reportExperimental brain research2022

Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury.

Timothy S Pulverenti, Morad Zaaya, Maria Knikou

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Timothy S PulverentiKlab4Recovery Research Laboratory, Department of Physical Therapy, College of Staten Island, The City University of New York, 2800 Victory Blvd, Bldg. 5N-207, Staten Island, NY, 10314, USA. timothy.pulverenti@csi.cuny.edu.ORCID http://orcid.org/0000-0003-0981-2286
Morad ZaayaKlab4Recovery Research Laboratory, Department of Physical Therapy, College of Staten Island, The City University of New York, 2800 Victory Blvd, Bldg. 5N-207, Staten Island, NY, 10314, USA.ORCID http://orcid.org/0000-0001-5500-607X
Maria KnikouKlab4Recovery Research Laboratory, Department of Physical Therapy, College of Staten Island, The City University of New York, 2800 Victory Blvd, Bldg. 5N-207, Staten Island, NY, 10314, USA.ORCID http://orcid.org/0000-0002-6277-236X
College of Staten Island · USMaimonides Medical Center · USThe Graduate Center, CUNY · US

Funding

Priming with High-Frequency Trans-spinal Stimulation to Augment Locomotor Training Benefits in Spinal Cord InjuryR01HD100544 · NICHD · COLLEGE OF STATEN ISLAND · PI HAREL, NOAM Y., KNIKOU, MARIA · 2020 to 2023
$2.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R01HD100544New York State Department of Health - Wadsworth Center C32095GGNew York State Department of Health - Wadsworth Center C33276GGNICHD NIH HHS R01 HD100544
6 · The paper itself

Abstract

Neurorecovery from locomotor training is well established in human spinal cord injury (SCI). However, neurorecovery resulting from combined interventions has not been widely studied. In this randomized clinical trial, we established the tibialis anterior (TA) flexion reflex modulation pattern when transcranial magnetic stimulation (TMS) of the primary motor cortex was paired with transcutaneous spinal cord (transspinal) stimulation over the thoracolumbar region during assisted step training. Single pulses of TMS were delivered either before (TMS-transspinal) or after (transspinal-TMS) transspinal stimulation during the stance phase of the less impaired leg. Eight individuals with chronic incomplete or complete SCI received at least 20 sessions of paired stimulation during assisted step training. Each session consisted of 240 paired stimuli delivered over 10-min blocks for 1 h during robotic-assisted step training with the Lokomat6 Pro

Indexed as

Spinal CordSpinal Cord InjuriesBrainHumansMuscle, SkeletalReflexTranscranial Magnetic StimulationFlexion reflexLocomotor trainingPaired-associative stimulationRehabilitationSpinal cord injuryTMSTransspinal stimulation

Identifiers

PMID35513720
PMCPMC9215206
OpenAlexW4229012854

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.