ArticleJournal of exposure science & environmental epidemiology2023
Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009-2019).
Article in Journal of exposure science & environmental epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Phthalates as the silent saboteurs of male fertility via changes in semen quality: a systematic review.Reproductive biology and endocrinology : RB&E · 2026Pooled it
- A systematic review of evidence that environmental contaminant exposure impedes weight loss and glycemic control during calorie-restricted diets in humans.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Filling gaps in population estimates of phthalate exposure globally: A systematic review and meta-analysis of international biomonitoring data.International journal of hygiene and environmental health · 2025Pooled it
- A robust and validated method for the determination of 21 urinary metabolites of 15 plasticizers, including phthalates, DEHTP, and DINCH, by online SPE and liquid chromatography-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2026Article
- Phthalate and Terephthalate Mixtures, Cardiometabolic Risk Factors, and the Role of Oxidative Stress: Evidence from NHANES 2015-2018.Cardiovascular toxicology · 2026Article
- Review
- Occupation and urinary phthalate metabolite concentrations in a national survey of adults in Canada.Environmental health : a global access science source · 2026Article
- Pregnancy exposure to individual phthalate concentrations and their mixtures in relation to pediatric serum antibody response.European journal of epidemiology · 2026Article
- Placental toxicity of alternative plasticizers: Current knowledge and future directions.Reproductive toxicology (Elmsford, N.Y.) · 2026Review
- Evaluation of Plasticiser Levels, Phthalates and Bisphenols in Bahraini Subjects with and Without Type-2 Diabetes.Journal of xenobiotics · 2026Article
- Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology.Frontiers in neuroscience · 2026Article
- Phthalates exposure and serum uric acid level in patients with Crohn's disease: A cross-sectional study.PloS one · 2026Article
- Associations between urinary biomarkers of phthalates and phthalate alternatives and female sexual function in a North American cohort.The journal of sexual medicine · 2025Article
- Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort.Environment international · 2025Article
- Prenatal exposure to environmentally relevant low-dosage dibutyl phthalate reduces placental efficiency in CD-1 mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Exploring the toxicological effects of DOTP exposure on periodontitis by combining molecular docking and molecular dynamics simulations.Scientific reports · 2025Article
- Review
- Phthalates are detected in the follicular fluid of adolescents and oocyte donors with associated changes in the cumulus cell transcriptome.F&S science · 2025Article
- Research trends and hotspots of infertility and phthalate esters: a bibliometric and visualization analysis from 2001 to 2024.Frontiers in medicine · 2025Article
- A common phthalate replacement disrupts ovarian function in young adult mice.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany phthalates are environmental pollutants and toxic to humans. Following phthalate regulations, human exposure to phthalates has globally decreased with time in European countries, the US and Korea. Conversely, exposure to their substitutes DEHT and/or DINCH has increased. In other countries, including China, little is known on the time-trends in human exposure to these plasticizers.
objectiveWe aimed to estimate time-trends in the urinary concentrations of phthalates, DEHT, and DINCH metabolites, in general population from non-European countries, in the last decade.
methodsWe compiled human biomonitoring (HBM) data from 123 studies worldwide in a database termed "PhthaLit". We analyzed time-trends in the urinary concentrations of the excreted metabolites of various phthalates as well as DEHT and DINCH per metabolite, age group, and country/region, in 2009-2019. Additionally, we compared urinary metabolites levels between continents.
resultsWe found solid time-trends in adults and/or children from the US, Canada, China and Taiwan. DEHP metabolites decreased in the US and Canada. Conversely in Asia, 5oxo- and 5OH-MEHP (DEHP metabolites) increased in Chinese children. For low-weight phthalates, the trends showed a mixed picture between metabolites and countries. Notably, MnBP (a DnBP metabolite) increased in China. The phthalate substitutes DEHT and DINCH markedly increased in the US. SIGNIFICANCE: We addressed the major question of time-trends in human exposure to phthalates and their substitutes and compared the results in different countries worldwide. IMPACT: Phthalates account for more than 50% of the plasticizer world market. Because of their toxicity, some phthalates have been regulated. In turn, the consumption of non-phthalate substitutes, such as DEHT and DINCH, is growing. Currently, phthalates and their substitutes show high detection percentages in human urine. Concerning time-trends, several studies, mainly in Europe, show a global decrease in phthalate exposure, and an increase in the exposure to phthalate substitutes in the last decade. In this study, we address the important question of time-trends in human exposure to phthalates and their substitutes and compare the results in different countries worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.