Evidence map›Paper›PMID 35513573›Full record

Observational studyArchives of osteoporosis2022

A retrospective observational study of osteoporosis management after a fragility fracture in primary care.

Alan Bell, David L Kendler, Aliya A Khan, Marla Shapiro C M, Anne Morisset, Jean-Pierre Leung, Maureen Reiner, Stephen M Colgan, Lubomira Slatkovska, Millicent Packalen

Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in Archives of osteoporosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05937945 (Uncovering Osteoporosis Clinical Trials), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05937945 unknown statusnot on this mapstarted 2024, after this paper: background citation

Uncovering Osteoporosis Clinical Trials: Firsthand Patient Insights Into Clinical Trial Experiences

TypeobservationalSponsorPower Life Sciences Inc.Ran2024 to 2026Enrolled500ConditionsOsteoporosis
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Osteoporosis and post-fracture management in the primary care setting: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Family/caregiver influence on osteoporosis management for older people: an integrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Alan BellDepartment of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-1012-7334
David L KendlerDepartment of Medicine, Division of Endocrinology, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-7679-3965
Aliya A KhanDepartment of Medicine, Divisions of Endocrinology and Metabolism and Geriatrics, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0003-3733-8956
Marla Shapiro C MDepartment of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
Anne MorissetDepartment of Medicine, Division of Internal Medicine, Sherbrooke University, Sherbrooke, QC, Canada.
Jean-Pierre LeungDepartment of Family Medicine, University of Calgary, Calgary, AB, Canada.
Maureen ReinerAmgen Inc, Thousand Oaks, CA, USA.ORCID http://orcid.org/0000-0002-3768-5053
Stephen M ColganAmgen Inc, Thousand Oaks, CA, USA.
Lubomira SlatkovskaAmgen Canada Inc, Mississauga, ON, Canada.ORCID http://orcid.org/0000-0001-5027-7989
Millicent PackalenAmgen Canada Inc, Mississauga, ON, Canada. mhume@amgen.com.
Amgen (Canada) · CAAmgen (United States) · USUniversity of Toronto · CAMcMaster University · CAUniversité de Sherbrooke · CAUniversity of British Columbia · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many countries, osteoporosis is predominantly managed by primary care physicians; however, management after a fragility fracture has not been widely investigated. We describe osteoporosis care gaps in a real-world patient cohort. Our findings help inform initiatives to identify and overcome obstacles to effective management of patients after fragility fracture. PURPOSE: A fragility fracture is a major risk factor for subsequent fracture in adults aged ≥ 50 years. This retrospective observational study aimed to characterize post-fracture management in Canadian primary care.

methodsA total of 778 patients with an index fragility fracture (low-trauma, excluding small bones) occurring between 2014 and 2016 were identified from medical records at 76 primary care centers in Canada, with follow-up until January 2018.

resultsOf 778 patients (80.5% female, median age [IQR] 73 [64-80]), 215 were on osteoporosis treatment and 269 had osteoporosis diagnosis recorded prior to their index fracture. The median follow-up was 363 (IQR 91-808) days. Of patients not on osteoporosis treatment at their index fracture, 60.2% (n = 339/563) remained untreated after their index fracture and 62.2% (n = 23/37) continued untreated after their subsequent fracture. After their index fracture, fracture risk assessment (FRAX or CAROC) was not performed in 83.2% (n = 647/778) of patients, and 59.9% (n = 466/778) of patients did not receive bone mineral density testing. Of patients without osteoporosis diagnosis recorded prior to their index date, 61.3% (n = 300/489) remained undiagnosed after their index fracture. At least one subsequent fracture occurred in 11.5% (n = 86/778) of patients.

conclusionIn the primary care setting, fragility fracture infrequently resulted in osteoporosis treatment or fracture risk assessment, even after multiple fragility fractures. These results suggest a fragility fracture is not recognized as a major risk factor for subsequent fracture and its occurrence does not prompt primary care physicians to intervene. These data urge initiatives to identify and overcome obstacles to primary care physicians' effective management of patients after fragility fractures.

Indexed as

Bone Density Conservation AgentsOsteoporosisOsteoporotic FracturesAdultCanadaFemaleHumansMalePrimary Health CareRetrospective StudiesBone Density Conservation AgentsFractureOsteoporosisPrimary careReal-world dataSecondary prevention

Identifiers

PMID35513573
PMCPMC9072526
OpenAlexW4229048999

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.