Evidence map›Paper›PMID 35513513›Full record

ArticleMikrochimica acta2022

A ratiometric electrochemical DNA-biosensor for detection of miR-141.

Ali Khodadoust, Navid Nasirizadeh, Ramezan Ali Taheri, Mohammad Dehghani, Mostafa Ghanei, Hasan Bagheri

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Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  3. Nanomedicine Innovations for Lung Cancer Diagnosis and Therapy.ACS applied materials & interfaces · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ali KhodadoustApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Navid NasirizadehDepartment of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran.
Ramezan Ali TaheriNanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mohammad DehghaniDepartment of Textile and Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran.
Mostafa GhaneiChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hasan BagheriChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. h.bagheri@bmsu.ac.ir.ORCID http://orcid.org/0000-0003-2895-6189
Baqiyatallah University of Medical Sciences · IRIslamic Azad University, Yazd · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sensitive biosensor for the detection of miR-141 has been constructed. The DNA-biosensor is prepared by first immobilizing the thiolated methylene blue-labeled hairpin capture probe (MB-HCP) on two-layer nanocomposite film graphene oxide-chitosan@ polyvinylpyrrolidone-gold nanourchin modified glassy carbon electrode. We used the hematoxylin as an electrochemical auxiliary indicator in the second stage to recognize DNA hybridization via the square wave voltammetry (SWV) responses that record the accumulated hematoxylin on electrode surfaces. The morphology and chemical composition of nanocomposite was characterized using TEM, FE-SEM, and FT-IR techniques. The preparation stages of the DNA-biosensor were screened by electrochemical impedance spectroscopy and cyclic voltammetry. The proposed DNA-biosensor can distinguish miR-141 from a non-complementary and mismatch sequence. A detection limit of 0.94 fM and a linear range of 2.0 -5.0 × 10

Indexed as

Biosensing TechniquesCarcinoma, Non-Small-Cell LungLung NeoplasmsMicroRNAsDNAHematoxylinHumansMethylene BlueSpectroscopy, Fourier Transform InfraredDNAHematoxylinMethylene BlueMicroRNAsMIRN141 microRNA, humanBiosensorEarly DetectionElectrochemical biosensorsLung CancermiR-141

Identifiers

PMID35513513
OpenAlexW4229064065

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.