ArticleScientific reports2022
Gender differences in frailty transition and its prediction in community-dwelling old adults.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 64 citations in OpenAlex.
- A 90 g/day low-carbohydrate diet improved glycemic control without decreasing frailty in older patients with type 2 diabetes: A secondary analysis of a randomized controlled trial.Journal of diabetes investigation · 2025Trial
- Lack of Immune Resilience Negatively Affects Physical Resilience: Results From the InCHIANTI Follow-Up Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Associations of Cognitive Function and Physical Activity with Frailty: A Community-Based Study of Older Adults.Florence Nightingale journal of nursing · 2026Article
- Frailty in Parkinson's disease: time to integrate it into treatment decision-making?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Metabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Trajectory of frailty among the older people in a community setting: A cohort study from the Shizuoka Kokuho Database.Aging clinical and experimental research · 2026Article
- External validation of a US claims-based frailty indicator and development of a population-specific model for the German healthcare system.GeroScience · 2026Article
- Societal cost of frailty in Singapore: an overview to the cost of healthcare and informal caregiving for frail older adults by frailty status, a cross-sectional study.BMC health services research · 2026Article
- Frailty Through a One Health Lens: Biological Sex, Mental Health, and Oral Function in Physically Active Older Adults.International journal of environmental research and public health · 2026Observational
- Association between chronic pain and frailty among Chinese adults aged ≥ 60 years: a cross-sectional study.Internal and emergency medicine · 2026Article
- Article
- Early Postoperative Physical Frailty Reflects Functional Vulnerability and Predicts Prolonged Hospitalization After Major Cardiovascular Surgery.Life (Basel, Switzerland) · 2026Article
- Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026Review
- Gender-specific sociodemographic and lifestyle factors associated with frailty status among Korean older adults.PloS one · 2026Article
- The contribution of depression and anxiety to frailty in men and women: data from a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- Assessing the contributions of health deficits to frailty among older people in Sub-Saharan Africa: evidence from Côte d'Ivoire.BMC public health · 2025Article
- Two-year evolution of frailty status and predictive factors in Chinese older adults: a national longitudinal study.BMC geriatrics · 2025Article
- Impact of social vulnerability on frailty transition among older adults in China: a national two-year cohort study.Journal of global health · 2025Article
- Frailty and Oral Health: Associations with Candidiasis, Prosthesis Use, and Hyposalivation.Geriatrics (Basel, Switzerland) · 2025Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is very common in old age and often associated with adverse events. Transitioning between frailty states is possible in both directions (improvement and worsening) offering targets for interventions. Frailty is more prevalent in women, but little is known about the impact of gender on frailty transition. The aim of this study is to identify gender differences for frailty transition in older adults and to develop gender-stratified prognostic prediction models for frailty transition. We performed a longitudinal analyses of the Berlin Initiative (cohort) Study with a frailty follow-up of 2.1 years. Description of frailty transition using the frailty phenotype and development of prognostic prediction models using multivariable logistic regressions for transition (improvement or worsening) stratified by gender following the TRIPOD statement were performed. In total, the study population consisted of 1158 community-dwelling adults with a mean age of 84.4 years and of whom 55% were women. Out of 1158 participants 225 (19%) were robust, 532 (46%) prefrail and 401 (35%) frail. After 2.1 (IQR 2.0-2.3) years, half of the participants had transitioned between frailty states. Men worsened more often and those who were already frail died more often than women. Gender-stratified prediction models for frailty transition demonstrated that some predictors (age, self-rated health, cognitive impairment, baseline frailty status) were included in all models. While stroke, diabetes mellitus, smoking and glomerular filtration rate were unique predictors in the models for females, osteoarthritis, hospitalization and education were predictors in the models for males. There are gender differences in frailty transition rates, patterns and prediction. This supports the importance of considering gender when addressing frailty and targeting interventions in old age.
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