Evidence map›Paper›PMID 35512997›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Explainable Deep Learning Improves Physician Interpretation of Myocardial Perfusion Imaging.

Robert J H Miller, Keiichiro Kuronuma, Ananya Singh, Yuka Otaki, Sean Hayes, Panithaya Chareonthaitawee, Paul Kavanagh, Tejas Parekh, Balaji K Tamarappoo, Tali Sharir and 14 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Artificial Intelligence in Nuclear Cardiology.Journal of clinical medicine · 2025
    Review
  5. Article
  6. Article
  7. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Review
  9. Review
  10. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  11. Review
  12. Artificial Intelligence Algorithms Need to Be Explainable-or Do They?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Robert J H MillerDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Keiichiro KuronumaDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Ananya SinghDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Yuka OtakiDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Sean HayesDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Panithaya ChareonthaitaweeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Paul KavanaghDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Tejas ParekhDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Balaji K TamarappooDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Tali SharirDepartment of Nuclear Cardiology, Assuta Medical Centers, Tel Aviv, Israel and Ben Gurion University of the Negev, Beer Sheba, Israel.
Andrew J EinsteinDivision of Cardiology, Department of Medicine, and Department of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York.
Mathews B FishOregon Heart and Vascular Institute, Sacred Heart Medical Center, Springfield, Oregon.
Terrence D RuddyDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland.
Albert J SinusasSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Edward J MillerSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Timothy M BatemanCardiovascular Imaging Technologies LLC, Kansas City, Missouri; and.
Sharmila DorbalaDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts.
Marcelo Di CarliDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts.
Sebastien CadetDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Joanna X LiangDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Damini DeyDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Daniel S BermanDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Piotr J SlomkaDivision of Artificial Intelligence in Medicine, Department of Medicine, Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; Piotr.Slomka@cshs.org.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Quantitative Prediction of Disease and Outcomes from Next Generation SPECT and CTR01HL089765 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2007 to 2021
$6.1M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL089765
6 · The paper itself

Abstract

Artificial intelligence may improve accuracy of myocardial perfusion imaging (MPI) but will likely be implemented as an aid to physician interpretation rather than an autonomous tool. Deep learning (DL) has high standalone diagnostic accuracy for obstructive coronary artery disease (CAD), but its influence on physician interpretation is unknown. We assessed whether access to explainable DL predictions improves physician interpretation of MPI.

Indexed as

Coronary Artery DiseaseDeep LearningMyocardial Perfusion ImagingPhysiciansArtificial IntelligenceCoronary AngiographyHumansTomography, Emission-Computed, Single-Photonartificial intelligencedeep learningimplementation

Identifiers

PMID35512997
PMCPMC9635672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.