Evidence map›Paper›PMID 35512920›Full record

ArticleJACC. Cardiovascular interventions2022

Transcaval Versus Transaxillary TAVR in Contemporary Practice: A Propensity-Weighted Analysis.

Robert J Lederman, Vasilis C Babaliaros, John C Lisko, Toby Rogers, Paul Mahoney, Jason R Foerst, Jeremiah P Depta, Kamran I Muhammad, James M McCabe, Andrei Pop and 6 more

Open access · greenAbstract read
In one paragraph

Article in JACC. Cardiovascular interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 52 citations in OpenAlex.

  1. Percutaneous Transaxillary Access for Large-Bore Cardiovascular Interventions: Evidence, Technique, and Complication Management.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Transcaval Transcatheter Aortic Valve Replacement: Clinical Outcomes From a TAVI Program Without Prior Transcaval Experience.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. [Advances in stroke after transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  12. Article
  13. SCAI Expert Consensus Statement on Alternative Access for Transcatheter Aortic Valve Replacement.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Cerebrovascular events after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Robert J LedermanCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: lederman@nih.gov.
Vasilis C BabaliarosEmory Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, Georgia, USA.
John C LiskoEmory Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Toby RogersCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Paul MahoneyDivision of Cardiology, The Sentara Heart Center, Norfolk, Virginia, USA.
Jason R FoerstCarilion Clinic, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.
Jeremiah P DeptaDepartment of Cardiology, Sands Constellation Heart Institute, Rochester Regional Health, Rochester, New York, USA.
Kamran I MuhammadOklahoma Heart Institute, Tulsa, Oklahoma, USA.
James M McCabeDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
Andrei PopAMITA Health Alexian Brothers Medical Center, Elk Grove Village, Illinois, USA.
Jaffar M KhanCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christopher G BruceCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Giorgio A MedrandaSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Jane W WeiDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Jose N BinongoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Adam B GreenbaumEmory Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: https://twitter.com/AdamGreenbaumMD.
National Institutes of Health · USEmory University · USMedStar Washington Hospital Center · USValve (United States) · USAlexian Brothers Medical Center · USCarilion Clinic · USOklahoma Heart Institute · USSentara Heart Hospital · USTwitter (United States) · USUnity Health System · USUniversity of Washington Medical Center · US

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
Real-time MRI guided cardiovascular interventionZIAHL005062 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2009 to 2025
$21.6M
Diagnostic and interventional cardiovascular catheterizationZIDHL006061 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$18.2M
Framingham Project/LevyZ01HL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2008 to 2008
$1.1M
Intramural NIH HHS Z01 HL006001Intramural NIH HHS ZIA HL006040
6 · The paper itself

Abstract

objectivesThe aim of this study was to compare transcaval and transaxillary artery access for transcatheter aortic valve replacement (TAVR) at experienced medical centers in contemporary practice.

backgroundThere are no systematic comparisons of transcaval and transaxillary TAVR access routes.

methodsEight experienced centers contributed local data collected for the STS/ACC TVT Registry (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry) between 2017 and 2020. Outcomes after transcaval and axillary/subclavian (transaxillary) access were adjusted for baseline imbalances using doubly robust (inverse propensity weighting plus regression) estimation and compared.

resultsTranscaval access was used in 238 procedures and transaxillary access in 106; for comparison, transfemoral access was used in 7,132 procedures. Risk profiles were higher among patients selected for nonfemoral access but similar among patients requiring transcaval and transaxillary access. Stroke and transient ischemic attack were 5-fold less common after transcaval than transaxillary access (2.5% vs 13.2%; OR: 0.20; 95% CI: 0.06-0.72; P = 0.014) compared with transfemoral access (1.7%). Major and life-threatening bleeding (Valve Academic Research Consortium 3 ≥ type 2) were comparable (10.0% vs 13.2%; OR: 0.66; 95% CI: 0.26-1.66; P = 0.38) compared with transfemoral access (3.5%), as was blood transfusion (19.3% vs 21.7%; OR: 1.07; 95% CI: 0.49-2.33; P = 0.87) compared with transfemoral access (7.1%). Vascular complications, intensive care unit and hospital length of stay, and survival were similar between transcaval and transaxillary access. More patients were discharged directly home and without stroke or transient ischemic attack after transcaval than transaxillary access (87.8% vs 62.3%; OR: 5.19; 95% CI: 2.45-11.0; P < 0.001) compared with transfemoral access (90.3%).

conclusionsPatients undergoing transcaval TAVR had lower rates of stroke and similar bleeding compared with transaxillary access in a contemporary experience from 8 US centers. Both approaches had more complications than transfemoral access. Transcaval TAVR access may offer an attractive option.

Indexed as

Aortic Valve StenosisIschemic Attack, TransientStrokeTranscatheter Aortic Valve ReplacementAortic ValveHumansRegistriesRisk FactorsTreatment OutcomeUnited Statesalternative accessnonfemoral accesspercutaneous accesssubclavian accesstransaxillary accesstranscaval access

Identifiers

PMID35512920
PMCPMC9138050
OpenAlexW4225265933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.