ArticleLife science alliance2022
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome.
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Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Role of miRNA in Cardiovascular Diseases in Children-Systematic Review.International journal of molecular sciences · 2024Pooled it
- Identification of Candidate miRNAs Associated with Shear Force and Intramuscular Fat in Pig Breeds.Foods (Basel, Switzerland) · 2026Article
- Integrated analysis of phenotypes and whole-transcriptome data for the preliminary exploration of molecular regulatory networks influencing beef quality.Food chemistry. Molecular sciences · 2026Article
- Identification of biomarkers associated with pathological dynamic progression in dystrophinopathies.Scientific reports · 2026Article
- Skeletal Muscle miRNA Patterns in High-Altitude Trekkers: Exploratory Identification of Molecular Signatures of Cellular and Endocrine Adaptation.Biomolecules · 2026Article
- The miR-30c-5p/SOCS3 axis is a potential driver of inflammation and metabolic imbalance in Duchenne muscular dystrophy.Frontiers in cell and developmental biology · 2026Article
- Exosomes Derived From Mesenchymal Stem Cells Regulating Myotube Cell Atrophy via NF-κB Signaling Pathway.Stem cells international · 2026Article
- Molecular Insights into the Regulatory Mechanisms Mediated by Hypoxia-Conditioned Skeletal Muscle Exosomal miRNAs.Biomarker insights · 2026Article
- Inhibition of TRPC3-Nox2 Complex Formation Ameliorates Skeletal Muscle Atrophy.Antioxidants (Basel, Switzerland) · 2025Article
- Local Non-Coding Regulatory Elements in Muscular Dystrophies.International journal of molecular sciences · 2025Review
- Moderate Chronic Treadmill Exercise Slows Dopaminergic Neuron Loss in a Rat Model of Parkinson's Disease and Alters RNA Content of Circulating Plasma Exosomes.Journal of neuroscience research · 2025Article
- Effects of Epicatechin on the Expression of MyomiRs-31, -133, -136, -206, -296, and -486 in the Skeletal Muscle of the Offspring of Obese Mothers.Cell biochemistry and biophysics · 2025Article
- microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy.Molecular therapy. Nucleic acids · 2025Article
- RNA signaling in skeletal muscle: the central role of microRNAs and exosomal microRNAs.Frontiers in cell and developmental biology · 2025Review
- Review
- Article
- Combined miRNA transcriptome and proteome analysis of extracellular vesicles in urine and blood from the Pompe mouse model.Annals of medicine · 2024Article
- Time-series transcriptomics reveals distinctive mRNA expression dynamics associated with gene ontology specificity and protein expression in skeletal muscle after electrical stimulation-induced resistance exercise.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise.Journal of physiology and biochemistry · 2024Review
- Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.BMC genomics · 2024Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Adrienne SamaniDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA.
Rylie M HightowerDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA.
Andrea L ReidDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA.
Katherine G EnglishDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-2757-5157
Michael A LopezDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-3029-0761
J Scott DoyleDepartment of Orthopedic Surgery, at the University of Alabama at Birmingham, Birmingham, AL, USA.
Michael J ConklinDepartment of Orthopedic Surgery, at the University of Alabama at Birmingham, Birmingham, AL, USA.
David A SchneiderDepartment of Biochemistry and Molecular Genetics at the University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-0635-5091
Marcas M BammanUniversity of Alabama at Birmingham Center for Exercise Medicine (UCEM), Birmingham, AL, USA.
Jeffrey J WidrickDivision of Genetics and Genomics at Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-5597-1141
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0981-169X
Min XieDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA.
David JeeDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
Eric C LaiDevelopmental Biology Program, Sloan Kettering Institute, New York, NY, USA.ORCID 0000-0002-8432-5851
Matthew S AlexanderDepartment of Pediatrics, Division of Neurology at Children's of Alabama and the University of Alabama at Birmingham, Birmingham, AL, USA matthewalexander@uabmc.edu.ORCID 0000-0001-7406-5171
University of Alabama at Birmingham · USChildren's of Alabama · USCornell University · USBoston Children's Hospital · USCivitan International · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MWhy is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9MThe Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7MSelective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8MRehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M · 2015 to 2019
$7.1MMolecular and genetic analysis of novel Slicer-dependent miRNA pathways in bloodR01HL135564 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI KHARAS, MICHAEL, LAI, ERIC C · 2017 to 2020
$2.9MUNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYONDR35GM140710 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2021 to 2025
$2.1MEnhancing Autophagy and Mitochondrial Biogenesis to Mitigate Cardiac Reperfusion InjuryR01HL153501 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI XIE, MIN · 2020 to 2024
$2.0MA MIR-486/DOCK3 SIGNALING AXIS MODULATES DYSTROPHIN-DEFICIENT PATHOLOGYR01HD095897 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALEXANDER, MATTHEW SCOTT · 2018 to 2022
$1.6MUAB Training Program In NeuroscienceT32NS095775 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2017 to 2026
$1.6MSmad8 is a driver of Duchenne muscular dystrophy pathology via myomiR repressionK08NS120812 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOPEZ, MICHAEL ALONZO · 2021 to 2025
$1.1MMicro RNAs as biomarkers and therapeutic targets in myotubular myopathyR21AR074006 · NIAMS · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI ALEXANDER, MATTHEW SCOTT, DOWLING, JAMES J · 2018 to 2019
$337kNCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL135564NHLBI NIH HHS R01 HL153501NHLBI NIH HHS R03 HL141620NIAMS NIH HHS R21 AR074006NIAMS NIH HHS U01 AR071133NICHD NIH HHS P2C HD086851NICHD NIH HHS R01 HD095897NIDDK NIH HHS P30 DK056336NIGMS NIH HHS R01 GM083300NIGMS NIH HHS R35 GM140710NINDS NIH HHS F99 NS118718NINDS NIH HHS K08 NS120812NINDS NIH HHS T32 NS095775
Abstract
miR-486 is a muscle-enriched microRNA, or "myomiR," that has reduced expression correlated with Duchenne muscular dystrophy (DMD). To determine the function of miR-486 in normal and dystrophin-deficient muscles and elucidate miR-486 target transcripts in skeletal muscle, we characterized
Indexed as
DystrophinMicroRNAsAnimalsMiceMice, Inbred mdxMuscle, SkeletalTranscriptomeDystrophinMicroRNAsMIRN486 microRNA, mouse
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.