Evidence map›Paper›PMID 35512801›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2022

Optimized S-nitrosohemoglobin Synthesis in Red Blood Cells to Preserve Hypoxic Vasodilation Via

Alfred Hausladen, Zhaoxia Qian, Rongli Zhang, Richard T Premont, Jonathan S Stamler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Control of tissue oxygenation by S-nitrosohemoglobin in human subjects.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alfred HausladenInstitute for Transformative Molecular Medicine (A.H., Z.Q., R.Z., R.T.P., J.S.S.), and Cardiovascular Research Institute (R.Z.), Case Western Reserve University School of Medicine, Cleveland, Ohio; and Harrington Discovery Institute (R.T.P., J.S.S.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Zhaoxia QianInstitute for Transformative Molecular Medicine (A.H., Z.Q., R.Z., R.T.P., J.S.S.), and Cardiovascular Research Institute (R.Z.), Case Western Reserve University School of Medicine, Cleveland, Ohio; and Harrington Discovery Institute (R.T.P., J.S.S.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Rongli ZhangInstitute for Transformative Molecular Medicine (A.H., Z.Q., R.Z., R.T.P., J.S.S.), and Cardiovascular Research Institute (R.Z.), Case Western Reserve University School of Medicine, Cleveland, Ohio; and Harrington Discovery Institute (R.T.P., J.S.S.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Richard T PremontInstitute for Transformative Molecular Medicine (A.H., Z.Q., R.Z., R.T.P., J.S.S.), and Cardiovascular Research Institute (R.Z.), Case Western Reserve University School of Medicine, Cleveland, Ohio; and Harrington Discovery Institute (R.T.P., J.S.S.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Jonathan S StamlerInstitute for Transformative Molecular Medicine (A.H., Z.Q., R.Z., R.T.P., J.S.S.), and Cardiovascular Research Institute (R.Z.), Case Western Reserve University School of Medicine, Cleveland, Ohio; and Harrington Discovery Institute (R.T.P., J.S.S.), University Hospitals Cleveland Medical Center, Cleveland, Ohio jss156@case.edu.
Case Western Reserve University · USUniversity Hospitals Case Medical Center · US

Funding

Regulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2004 to 2019
$26.1M
Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Restoration and Function of S-Nitrosothiol in Stored BloodR01HL126900 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER · 2016 to 2026
$5.0M
Novel Regulation of Renal Function by S-NitrosylationR01DK119506 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER, Hualin Zhou · 2018 to 2026
$3.7M
NHLBI NIH HHS P01 HL075443NHLBI NIH HHS P01 HL128192NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL126900NIDDK NIH HHS R01 DK119506
6 · The paper itself

Abstract

Classic physiology links tissue hypoxia to oxygen delivery through control of microvascular blood flow (autoregulation of blood flow). Hemoglobin (Hb) serves both as the source of oxygen and the mediator of microvascular blood flow through its ability to release vasodilatory S-nitrosothiol (SNO) in proportion to degree of hypoxia.

Indexed as

S-NitrosothiolsVasodilationAnimalsbeta-GlobinsErythrocytesHemoglobinsHypoxiaMiceMicrocirculationNitric OxideOxygenbeta-GlobinsHemoglobinsNitric OxideOxygenS-nitrosohemoglobinS-Nitrosothiols

Identifiers

PMID35512801
PMCPMC10389762
OpenAlexW4229006516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.