ReviewYonsei medical journal2022
Platelet Function and Genotype after DES Implantation in East Asian Patients: Rationale and Characteristics of the PTRG-DES Consortium.
Review in Yonsei medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04734028 (Platelet Function and genoType-Related Long-term progGosis in DES-treated Patients), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Platelet Function and genoType-Related Long-term progGosis in DES-treated Patients : A Consortium From Multi-centered Registries
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Sex Differences in Midterm Prognostic Implications of High Platelet Reactivity After Percutaneous Coronary Intervention With Drug-Eluting Stents in East Asian Patients: Results From the PTRG-DES (Platelet Function and Genotype-Related Long-Term Prognosis in Drug-Eluting Stent-Treated Patients With Coronary Artery Disease) Consortium.Journal of the American Heart Association · 2023Trial
- Drug-Coated Balloon-Based Versus Drug-Eluting Stent-Only Strategy in Stable Angina and Acute Coronary Syndrome: A Propensity-Score Overlap-Weighted Analysis.Journal of clinical medicine · 2026Article
- Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug-Eluting Stent Implantation.Journal of the American Heart Association · 2026Article
- Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction.Journal of the American Heart Association · 2026Article
- Drug-Coated Balloon-Based Intervention for De Novo Acute Myocardial Infarction.Yonsei medical journal · 2025Observational
- The efficacy and safety of prasugrel in acute coronary syndrome: a propensity-matched Korean cohort study focused on age and weight of patients.BMC cardiovascular disorders · 2025Observational
- Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting.The Korean journal of internal medicine · 2025Article
- Clinical impact of drug-coated balloon treatment of coronary artery disease in elderly patients.Journal of geriatric cardiology : JGC · 2025Article
- Impact of haemoglobinA1c on platelet reactivity and cardiovascular outcomes in patients undergoing drug-eluting stent implantation.Scientific reports · 2024Article
- Long-term efficacy of drug-coated balloon-based treatment for de novo left anterior descending artery disease.Scientific reports · 2024Article
- Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation.BMC medicine · 2024Article
- Impact of Drug-Coated Balloon-Based Revascularization in Patients with Chronic Total Occlusions.Journal of clinical medicine · 2024Article
- Prognostic Impact ofJournal of the American Heart Association · 2024Article
- Different association of atherogenic index of plasma with the risk of high platelet reactivity according to the presentation of acute myocardial infarction.Scientific reports · 2024Article
- Association of Age- and Body Mass Index-Stratified High On-Treatment Platelet Reactivity With Coronary Intervention Outcomes in East Asian Patients.Journal of the American Heart Association · 2024Article
- Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium.JACC. Asia · 2024Article
- Prognostic Implication of Platelet Reactivity According to Left Ventricular Systolic Dysfunction Status in Patients Treated With Drug-Eluting Stent Implantation: Analysis of the PTRG-DES Consortium.Journal of Korean medical science · 2024Article
- High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation.Scientific reports · 2024Article
- Implication of diabetic status on platelet reactivity and clinical outcomes after drug-eluting stent implantation: results from the PTRG-DES consortium.Cardiovascular diabetology · 2023Article
- Long-Term Clinical Outcomes of Drug-Coated Balloon Treatment for De Novo Coronary Lesions.Yonsei medical journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePlatelet function test (PFT) results and genotype hold unique prognostic implications in East Asian patients. The aim of the PTRG-DES (Platelet function and genoType-Related long-term proGnosis in Drug-Eluting Stent-treated Patients with coronary artery disease) consortium is to assess the clinical impact thereof on long-term clinical outcomes in Korean patients with coronary artery disease during dual antiplatelet therapy (DAPT) including clopidogrel. MATERIALS AND
methodsSearching publications on the PubMed, we reviewed clopidogrel treatment studies with PFT and/or genotype data for potential inclusion in this study. Lead investigators were invited to share PFT/genotype results, patient characteristics, and clinical outcomes to evaluate relationships among them.
resultsNine registries from 32 academic centers participated in the PTRG-DES consortium, contributing individual patient data from 13160 patients who underwent DES implantation between July 2003 and August 2018. The PTRG-PFT cohort was composed of 11714 patients with available VerifyNow assay results. Platelet reactivity levels reached 218±79 P2Y12 reaction units (PRU), and high on-clopidogrel platelet reactivity based on a consensus-recommended cutoff (PRU >208) was observed in 55.9%. The PTRG-Genotype cohort consisted of 8163 patients with candidate genotypes related with clopidogrel responsiveness. Of those with cytochrome P450 (CYP) 2C19 genotype, frequencies of carrying one and two loss-of-function allele (s) (
conclusionThe PTRG-DES consortium highlights unique values for on-clopidogrel platelet reactivity and CYP2C19 phenotype that may be important to developing optimal antiplatelet regimens in East Asian patients.
trial registrationClinicalTrials.gov Identifier: NCT04734028.
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