ArticleCell systems2022
Localized electrical stimulation triggers cell-type-specific proliferation in biofilms.
Article in Cell systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Self-generated hydrogel ejects bacterial cells for localized biofilm dispersion.Nature microbiology · 2026Article
- Computational model of fractal interface formation in bacterial biofilms.Physical review. E · 2025Article
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Bioelectronic Delivery of Potassium Ions Controls Membrane Voltage and Growth Dynamics in Bacteria Biofilms.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Photocontrol of bacterial membrane potential regulates antibiotic persistence inEuropean physical journal plus · 2025Article
- Bioelectronic Drug-free Control of Opportunistic Pathogens through Selective Excitability.Device · 2024Article
- Materials-driven strategies in bacterial engineering.MRS communications · 2024Review
- Bioelectrical State of Bacteria Is Linked to Growth Dynamics and Response to Neurotransmitters: Perspectives for the Investigation of the Microbiota-Brain Axis.International journal of molecular sciences · 2023Article
- Modeling control and transduction of electrochemical gradients in acid-stressed bacteria.iScience · 2023Article
- Living electronics: A catalogue of engineered living electronic components.Microbial biotechnology · 2023Review
- Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Programmable Electrochemical Stimulation on a Large-Scale CMOS Microelectrode Array.IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Biological systems ranging from bacteria to mammals utilize electrochemical signaling. Although artificial electrochemical signals have been utilized to characterize neural tissue responses, the effects of such stimuli on non-neural systems remain unclear. To pursue this question, we developed an experimental platform that combines a microfluidic chip with a multielectrode array (MiCMA) to enable localized electrochemical stimulation of bacterial biofilms. The device also allows for the simultaneous measurement of the physiological response within the biofilm with single-cell resolution. We find that the stimulation of an electrode locally changes the ratio of the two major cell types comprising Bacillus subtilis biofilms, namely motile and extracellular-matrix-producing cells. Specifically, stimulation promotes the proliferation of motile cells but not matrix cells, even though these two cell types are genetically identical and reside in the same microenvironment. Our work thus reveals that an electronic interface can selectively target bacterial cell types, enabling the control of biofilm composition and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.