Evidence map›Paper›PMID 35512681›Full record

ArticleThe American journal of hospice & palliative care2023

Team-Based Hospice Referrals: A Potential Quality Metric for Lung Cancer in the Immunotherapy Era.

Thomas W Lycan, Alyssa Buckenheimer, Jimmy Ruiz, Gregory Russell, Andy Shipe Dothard, Tamjeed Ahmed, Stefan Grant, Carl Grey, William J Petty

Abstract read
In one paragraph

Article in The American journal of hospice & palliative care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Scoping review of anticancer drug utilization in lung cancer patients at the end of life.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas W LycanHematology and Oncology, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-9475-1558
Alyssa BuckenheimerHospice abd Palliative Medicine, 12317University of Pittsburgh, Pittsburgh, PA, USA.
Jimmy RuizHematology and Oncology, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.
Gregory RussellBiostatistics and Data Science, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.
Andy Shipe DothardHematology and Oncology, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.
Tamjeed AhmedHematology and Oncology, 219711Tennessee Oncology, Gallatin, TN, USA.
Stefan GrantHematology and Oncology, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.
Carl GreyHospice abd Palliative Medicine, 12317University of Pittsburgh, Pittsburgh, PA, USA.
William J PettyHematology and Oncology, 12279Wake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

backgroundImmune checkpoint inhibitors (ICIs) can lead to durable responses in patients with lung cancer but may delay transitions to hospice at the end of life (EOL). We aimed to test the association of continuity of care with EOL outcomes in the ICI era.

methodsWe collected retrospective data on all patients with lung cancer who started ICI treatment at a single comprehensive cancer center in the United States (1/1/14-5/1/18) and subsequently died. We defined a hospice referral as having continuity of care if placed by a provider from the patient's multidisciplinary cancer team (e.g., a medical oncologist, palliative care specialist, intensivist, and hospitalist).

resultsIn this cohort of 143 patients, 58% had a team-based hospice referral which was associated with a lower risk of death in the hospital. The most common reason patients declined hospice at EOL was an unwillingness to discontinue cancer-directed therapy. As compared to a similar historical cohort of patients treated with chemotherapy alone (2008-2010), there was a similar rate of hospice referral (68% vs 74%) but higher rates of new systemic therapy initiated within 30 days of death (17% vs 6%, p .001) and last dose within 14 days of death (13% vs 5%, p .005).

conclusionsFuture studies should test the continuity of care at EOL as a new quality metric for advanced NSCLC.

Indexed as

Hospice CareHospicesLung NeoplasmsNeoplasmsTerminal CareHumansImmunotherapyPalliative CareReferral and ConsultationRetrospective StudiesUnited Statescontinuity of carehospice careimmunotherapylung canceroncologypalliative carequality metric

Identifiers

PMID35512681
PMCPMC9815203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.