Evidence map›Paper›PMID 35512664›Full record

ArticleActa cytologica2022

Effects of Rapid On-Site Evaluation on Diagnostic Accuracy of Thyroid Fine-Needle Aspiration.

Celia Fawcett, Serenella Eppenberger-Castori, Stefan Zechmann, Jasmin Hanke, Michelle Herzog, Spasenija Savic Prince, Emanuel Remigius Christ, Fahim Ebrahimi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cytologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Celia FawcettDivision of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland.
Serenella Eppenberger-CastoriPathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Stefan ZechmannDivision of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland.
Jasmin HankePathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Michelle HerzogPathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Spasenija Savic PrincePathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Emanuel Remigius ChristDivision of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland.
Fahim EbrahimiDivision of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFine-needle aspiration (FNA) is well-established for the evaluation of suspicious thyroid nodules. However, a significant proportion is nondiagnostic. Rapid on-site evaluation (ROSE) has been proposed to improve the overall adequacy of FNA.

methodsRetrospective cohort study comparing adequacy of thyroid FNA findings pre- and postimplementation of ROSE at a tertiary center in Switzerland. Patients undergoing thyroid FNA from January 2016 to December 2019 were included. The primary outcome was the rate of nondiagnostic findings (Bethesda System for Reporting Thyroid Cytopathology category I).

resultsIn total, 410 thyroid nodule FNAs were performed. Of those, 309 with standard FNA and 101 with ROSE. The majority of patients were female (71%), with a median age of 56 years (IQR 46-68) and a nodule diameter of 1.9 cm (IQR 1.2-2.9). Implementation of ROSE led to a decrease in nondiagnostic findings from 41.1% to 23.8%, with an odds ratio of 0.42 (95% CI: 0.24-0.72; p = 0.002). Implementation of ROSE was associated with significantly higher rates of Bethesda category III (27.7% vs. 19.1%), category IV (15.8% vs. 5.5%), and Bethesda category VI (6.9% vs. 2.3%). Repeated FNA was performed in 29.1% before and 20.8% after implementation of ROSE (p = 0.18). The mean number of FNA per nodule was reduced from 1.4 (0.6) to 1.2 (0.4) with ROSE (p = 0.04).

conclusionsImplementation of ROSE of thyroid nodule specimen improved diagnostic adequacy of FNA, reducing nondiagnostic findings. However, due to increased equivocal findings (Bethesda category III), there was no significant reduction of repeat FNA.

Indexed as

Thyroid NeoplasmsThyroid NoduleAgedBiopsy, Fine-NeedleFemaleHumansMaleMiddle AgedRapid On-site EvaluationRetrospective StudiesCytologyFine-needle aspirationOn-site evaluationThyroid nodule

Identifiers

PMID35512664
PMCPMC9501752
OpenAlexW4229000911

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.