Evidence map›Paper›PMID 35512290›Full record

ArticleEuropean heart journal2022

Cardiac magnetic resonance identifies raised left ventricular filling pressure: prognostic implications.

Pankaj Garg, Rebecca Gosling, Peter Swoboda, Rachel Jones, Alexander Rothman, Jim M Wild, David G Kiely, Robin Condliffe, Samer Alabed, Andrew J Swift

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Pankaj GargDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0002-5483-169X
Rebecca GoslingDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0001-7465-3563
Peter SwobodaThe Institute of Cardiovascular and Metabolic Medicine, University of Leeds, UK.ORCID 0000-0001-7162-7079
Rachel JonesDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0003-4699-1981
Alexander RothmanDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0002-7847-4500
Jim M WildDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0002-7246-8660
David G KielyDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
Robin CondliffeSheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Samer AlabedDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0002-9960-7587
Andrew J SwiftDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
University of Sheffield · GBSheffield Teaching Hospitals NHS Foundation Trust · GBUniversity of East Anglia · GBUniversity of Leeds · GB

Funding

British Heart Foundation SP/14/6/31350Department of Health NIHR-RP-R3-12-027Medical Research Council MR/M008894/1Wellcome Trust 205188/Z/16/ZWellcome Trust 215799/Z/19/ZWellcome Trust 220703/Z/20/Z
6 · The paper itself

Abstract

aimsNon-invasive imaging is routinely used to estimate left ventricular (LV) filling pressure (LVFP) in heart failure (HF). Cardiovascular magnetic resonance (CMR) is emerging as an important imaging tool for sub-phenotyping HF. However, currently, LVFP cannot be estimated from CMR. This study sought to investigate (i) if CMR can estimate LVFP in patients with suspected HF and (ii) if CMR-modelled LVFP has prognostic power. METHODS AND

resultsSuspected HF patients underwent right heart catheterization (RHC), CMR and transthoracic echocardiography (TTE) (validation cohort only) within 24 h of each other. Right heart catheterization measured pulmonary capillary wedge pressure (PCWP) was used as a reference for LVFP. At follow-up, death was considered as the primary endpoint. We enrolled 835 patients (mean age: 65 ± 13 years, 40% male). In the derivation cohort (n = 708, 85%), two CMR metrics were associated with RHC PCWP:LV mass and left atrial volume. When applied to the validation cohort (n = 127, 15%), the correlation coefficient between RHC PCWP and CMR-modelled PCWP was 0.55 (95% confidence interval: 0.41-0.66, P < 0.0001). Cardiovascular magnetic resonance-modelled PCWP was superior to TTE in classifying patients as normal or raised filling pressures (76 vs. 25%). Cardiovascular magnetic resonance-modelled PCWP was associated with an increased risk of death (hazard ratio: 1.77, P < 0.001). At Kaplan-Meier analysis, CMR-modelled PCWP was comparable to RHC PCWP (≥15 mmHg) to predict survival at 7-year follow-up (35 vs. 37%, χ2 = 0.41, P  = 0.52).

conclusionA physiological CMR model can estimate LVFP in patients with suspected HF. In addition, CMR-modelled LVFP has a prognostic role.

Indexed as

Cardiac CatheterizationHeart FailureAgedFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPrognosisPulmonary Wedge PressureStroke VolumeVentricular Function, LeftCardiovascular magnetic resonanceLeft ventricular filling pressureRight heart catheterization

Identifiers

PMID35512290
PMCPMC9259376
OpenAlexW4226069314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.