SynthesisRheumatology (Oxford, England)2022
Musculoskeletal ultrasound for treating rheumatoid arthritis to target-a systematic literature review.
Synthesis in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Infrared thermography in the detection of arthritis: a systematic review of diagnostic performance compared with joint ultrasound.Rheumatology international · 2026Pooled it
- Vision transformer-based ordinal model for semi-quantitative synovitis grading on musculoskeletal ultrasound: a retrospective study with internal and external validation.Annals of medicine · 2026Article
- Microvascular imaging is superior to power doppler in synovitis vascular flow detection in rheumatoid arthritis using the OMERACT-EULAR scoring system.Arthritis research & therapy · 2026Article
- Advances in the Application of Musculoskeletal Ultrasound in the Diagnosis of Rheumatoid Arthritis: A Review.International journal of general medicine · 2026Review
- Serum ferritin as an independent biomarker of subclinical synovitis in rheumatoid arthritis patients in clinical remission or low disease activity.Frontiers in medicine · 2026Article
- Clinical and ultrasound remission at 48 weeks of upadacitinib in rheumatoid arthritis: real-world results from the Italian multicenter UPARAREMUS study.Arthritis research & therapy · 2025Observational
- Rheumatoid Arthritis: Biomarkers and the Latest Breakthroughs.International journal of molecular sciences · 2025Review
- Article
- Artificial intelligence in rheumatology: A transformative perspective.Journal of translational internal medicine · 2025Article
- Diagnostic Accuracy and Concordance of Standardized vs. Non-Standardized Joint Physical Examination for Assessing Disease Activity in Rheumatoid Arthritis: A Paired Comparison Using Ultrasound as Reference Standard.Journal of clinical medicine · 2025Article
- First metatarsophalangeal joint synovial hypertrophy associated with vitamin D status in type 2 diabetes mellitus: An ultrasound-graded study.World journal of diabetes · 2025Article
- The Role of Musculoskeletal Ultrasound in Biologic Drug Tapering and Relapse Monitoring: Findings from a One-Year Prospective Study in a Cohort of Rheumatoid Arthritis Patients in Sustained Clinical Remission.Diagnostics (Basel, Switzerland) · 2025Article
- Comparisons of [Clinical rheumatology · 2025Article
- Septic Arthritis Modeling Using Sonographic Fusion with Attention and Selective Transformation: a Preliminary Study.Journal of imaging informatics in medicine · 2025Article
- Mini-enthesitis can differentiate rheumatoid arthritis from psoriatic arthritis: A comprehensive comparative ultrasound study of the joints and mini-entheses of the hands.Archives of rheumatology · 2025Article
- Rheumatoid Factor: Diagnostic and Prognostic Performance and Therapeutic Implications in Rheumatoid Arthritis.Journal of clinical medicine · 2025Review
- Switch from Intravenous to Subcutaneous Formulation of Tocilizumab in Rheumatoid Arthritis: Retrospective Cohort Analysis and Systematic Literature Review.Biologics : targets & therapy · 2025Article
- Biomarkers in the diagnosis, prognosis and management of rheumatoid arthritis: A comprehensive review.Annals of clinical biochemistry · 2025Review
- From image to insight: leveraging imaging to empower patients with inflammatory arthropathies.Frontiers in medicine · 2025Review
- Iguratimod in combination with conventional therapy suppresses inflammation and improves joint structure and function in rheumatoid arthritis.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to systematically review the literature to retrieve evidence on the diagnostic and prognostic value of musculoskeletal ultrasound for a treat to target (T2T) approach in RA.
methodsEight research questions were developed addressing the role of ultrasound (including different ultrasound scores and elementary lesions) for diagnosis, monitoring and prognosis of RA. PubMed and EMBASE were searched (2005-2020). Articles on RA and reporting data on musculoskeletal ultrasound were included and extracted according to the underlying questions, and risk of bias assessed according to the study design.
resultsOut of 4632 records, 60 articles were included. Due to clinical heterogeneity, meta-analysis was not possible. Ultrasound better predicted disease relapses with respect to clinical examination in patients in remission, while both methods performed similarly in predicting response to therapy, achievement of remission and radiographic progression. Ultrasound was superior to clinical examination in diagnosing joint involvement using another imaging modality, such as magnetic resonance imaging, as reference. Limited ultrasound scores performed like more extensive evaluations for the detection of joint inflammation and for outcome prediction. Higher ultrasound scores of synovitis were linked to poor outcomes at all disease stages, but a specific cut-off distinguishing between low- and high-risk groups did not emerge.
conclusionsThese data confirm the pivotal role of ultrasound when evaluating synovial inflammation and when identifying RA patients at higher risk of relapse. Further research is needed to better define the role of ultrasound in a T2T management strategy in moderately-to-highly active RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.