ArticlePloS one2022
Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Toxicological and Physiological Responses to Combined Ultrasound and Lipid-Coated ZnO Nanoparticle Exposure inACS applied materials & interfaces · 2026Article
- Sonogenetics for precision medicine: from molecular toolkit to clinical translation.Theranostics · 2026Review
- Enhancing prestin oligomerization for superior sonogenetics.Theranostics · 2026Article
- Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation.Frontiers in neuroscience · 2026Review
- Recent advancement of sonogenetics: A promising noninvasive cellular manipulation by ultrasound.Genes & diseases · 2024Review
- Genetically encoded mediators for sonogenetics and their applications in neuromodulation.Frontiers in cellular neuroscience · 2023Review
- Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future.Frontiers in neuroscience · 2023Article
- A review of the bioeffects of low-intensity focused ultrasound and the benefits of a cellular approach.Frontiers in physiology · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Ultrasound has been shown to affect the function of both neurons and non-neuronal cells, but, the underlying molecular machinery has been poorly understood. Here, we show that at least two mechanosensitive proteins act together to generate C. elegans behavioral responses to ultrasound stimuli. We first show that these animals generate reversals in response to a single 10 msec pulse from a 2.25 MHz ultrasound transducer. Next, we show that the pore-forming subunit of the mechanosensitive channel TRP-4, and a DEG/ENaC/ASIC ion channel MEC-4, are both required for this ultrasound-evoked reversal response. Further, the trp-4;mec-4 double mutant shows a stronger behavioral deficit compared to either single mutant. Finally, overexpressing TRP-4 in specific chemosensory neurons can rescue the ultrasound-triggered behavioral deficit in the mec-4 null mutant, suggesting that both TRP-4 and MEC-4 act together in affecting behavior. Together, we demonstrate that multiple mechanosensitive proteins likely cooperate to transform ultrasound stimuli into behavioral changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.