ReviewThe Journal of clinical endocrinology and metabolism2022
Approach to the Patient: Hyponatremia and the Syndrome of Inappropriate Antidiuresis (SIAD).
Review in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Serotonergic Toxicity and Hyponatremia Associated with Antidepressant Therapy: The Pivotal Role of SIADH.Clinical drug investigation · 2026Review
- Chronic hyponatremia and skeletal vulnerability: bone loss, fragility fracture risk, and therapeutic uncertainties.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Article
- Antimicrobial-induced hyponatremia: pathophysiological mechanisms, implicated agents, and clinical management strategies.European journal of clinical pharmacology · 2026Review
- ApoA1 and ApoB Are Associated with Fracture Risk in Patients with Type 1 Diabetes.Journal of clinical medicine · 2026Article
- Hyponatremia: Evolving diagnostics and emerging therapeutics in clinical practice.World journal of nephrology · 2026Review
- Successful treatment of chronic alcohol-induced refractory hyponatremia with tolvaptan: a case report with in-depth analysis of traditional treatment failure mechanisms.Frontiers in pharmacology · 2026Article
- Refractory hyponatremia in small cell lung cancer: a case report and literature review.Frontiers in endocrinology · 2026Review
- Case of Severe Hiccups Causing SIADH, Treated With Lorazepam.Clinical case reports · 2025Article
- A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Induced by Selpercatinib in a Patient With RET Fusion Gene-Positive Non-Small Cell Lung Cancer.Respirology case reports · 2025Article
- Severe hyponatremia in a mild COVID-19 patient: diagnostic challenges of SIADH and adrenal insufficiency.CEN case reports · 2025Article
- Effectiveness of an Early Intervention in Mild Hyponatremia to Prevent Accidental Falls in Hospitalized Older Adults-A Crossover Ecological Clinical Trial.Healthcare (Basel, Switzerland) · 2025Article
- Syndrome of Inappropriate Antidiuresis.Journal of the American Society of Nephrology : JASN · 2025Review
- Characteristics, management and outcomes of patients with hyponatraemia presenting to an Irish tertiary hospital.Endocrine connections · 2025Article
- Fluid and Electrolyte Disorders in Traumatic Brain Injury: Clinical Implications and Management Strategies.Journal of clinical medicine · 2025Review
- Recurrent hyponatremia due to syndrome of inappropriate antidiuresis after traumatic brain injury: two case reports.Frontiers in endocrinology · 2025Article
- The Different Paths That Lead to Hypotonic Hyponatremia, and a Safe Approach to Treatment.Journal of clinical medicine · 2024Review
- Clinical study on the relationship between liver cirrhosis, ascites, and hyponatremia.World journal of gastrointestinal surgery · 2024Article
- [Consensus recommendations on the diagnosis and treatment of hyponatremia from the Austrian Society for Nephrology 2024].Wiener klinische Wochenschrift · 2024Article
- Long-term low-dose tolvaptan efficacy and safety in SIADH.Endocrine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hyponatremia is the most common electrolyte disturbance seen in clinical practice, affecting up to 30% of acute hospital admissions, and is associated with significant adverse clinical outcomes. Acute or severe symptomatic hyponatremia carries a high risk of neurological morbidity and mortality. In contrast, chronic hyponatremia is associated with significant morbidity including increased risk of falls, osteoporosis, fractures, gait instability, and cognitive decline; prolonged hospital admissions; and etiology-specific increase in mortality. In this Approach to the Patient, we review and compare the current recommendations, guidelines, and literature for diagnosis and treatment options for both acute and chronic hyponatremia, illustrated by 2 case studies. Particular focus is concentrated on the diagnosis and management of the syndrome of inappropriate antidiuresis. An understanding of the pathophysiology of hyponatremia, along with a synthesis of the duration of hyponatremia, biochemical severity, symptomatology, and blood volume status, forms the structure to guide the appropriate and timely management of hyponatremia. We present 2 illustrative cases that represent common presentations with hyponatremia and discuss the approach to management of these and other causes of hyponatremia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.