ArticleCerebral cortex (New York, N.Y. : 1991)2023
How distinct functional insular subdivisions mediate interacting neurocognitive systems.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Neural mechanisms of brand love relationship dynamics: Is the development of brand love relationships the same as that of interpersonal romantic love relationships?Frontiers in neuroscience · 2022Pooled it
- A neurocognitive account of complex PTSD: self-modelling, affective dysregulation, and implications for MDMA-assisted and targeted psychotherapies.European journal of psychotraumatology · 2026Review
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Article
- Modulating the Interplay Between Impulsivity and Interoception Through HD-tDCS to the Right Insula and Anterior Cingulate Cortex.Biomedicines · 2026Article
- Anterior Insula Drives Progressive Structural Brain Network Atrophy in the Behavioural Variant of Frontotemporal Dementia.Human brain mapping · 2025Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Insular Cortex-Biology and Its Role in Psychiatric Disorders: A Narrative Review.Brain sciences · 2025Review
- Neural mechanisms of confidence propagation in hierarchical partially observable decision-making.iScience · 2025Article
- The Anterior Insula Engages in Feature- and Context-Level Predictive Coding Processes for Recognition Judgments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Emotional salience network involved in constructing two-dimensional fear space in humans.Neurobiology of stress · 2025Review
- Women, intuition, and management-the Yin and Yang of nonconscious thought.Frontiers in psychology · 2025Article
- The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Brain mechanisms discriminating enactive mental simulations of running and plogging.Human brain mapping · 2024Article
- Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study.The journal of headache and pain · 2024Article
- Increased ventral anterior insular connectivity to sports betting availability indexes problem gambling.Addiction biology · 2024Article
- Age-related positive emotional reactivity decline associated with the anterior insula based resting-state functional connectivity.Human brain mapping · 2024Article
- High-dimensional Metaverse Platforms and the Virtually Extended Self.Journal of cognition · 2024Article
- Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional connectivity gradients of the insula to different cerebral systems.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent neurocognitive models propose that the insula serves as a hub of interoceptive awareness system, modulating 2 interplaying neurocognitive systems: The posterior insula (PI) receives and integrates various interoceptive signals; these signals are then transmitted to the anterior insula for processing higher-order representations into awareness, where the dorsal anterior insula (dAI) modulates the prefrontal self-control system and the ventral anterior insula (vAI) modulates the amygdala (AMG)-striatal reward-seeking circuit. We sought to test this view using a multimodal approach. We first used a resting-state functional magnetic resonance imaging (fMRI) approach with a sample of 120 undergraduate students. Then, we unpacked the neuro-cognitive association between insular connectivity and cognitive performance during an Iowa gambling fMRI task. Lastly, an independent Open Southwest University Longitudinal Imaging Multimodal dataset was used to validate the results. Findings suggested that the dAI was predominantly connected to the prefrontal regions; the vAI was primarily connected to the AMG-ventral-striatum system; and the PI was mainly connected to the visceral-sensorimotor system. Moreover, cognitive scores were positively correlated with FC between dAI and the self-control process of ventrolateral prefrontal cortex and were negatively correlated with FC between vAI and the reward-seeking process of orbitofrontal cortex and subgenual anterior cingulate cortex. The findings highlight the roles of our theorized subinsular functionality in the overall operation of the neural cognitive systems.
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