Evidence map›Paper›PMID 35511594›Full record

ArticleThe American journal of clinical nutrition2022

Dietary quality and risk of heart failure in men.

Xiao Gu, Dong D Wang, Teresa T Fung, Dariush Mozaffarian, Luc Djoussé, Bernard Rosner, Frank M Sacks, Walter C Willett

Open access · greenAbstract read
In one paragraph

Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Associations Between Perceived Tap Water Safety and Dietary Outcomes Among US Adults.Journal of the Academy of Nutrition and Dietetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiao GuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-2497-7695
Dong D WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Teresa T FungDepartment of Nutrition, Simmons University, Boston, MA, USA.ORCID 0000-0002-0159-482X
Dariush MozaffarianFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.ORCID 0000-0001-7958-9492
Luc DjousséDivision of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-9902-3047
Bernard RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6907-0056
Frank M SacksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-1341-1995
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-1458-7597
Brigham and Women's Hospital · USHarvard University · USSimmons University · USTufts University · US

Funding

Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
NCI NIH HHS U01 CA167552NHLBI NIH HHS R01 HL035464
6 · The paper itself

Abstract

backgroundDue to the increasing disease burden, strategies to predict and prevent heart failure (HF) are urgently needed.

objectiveWe aimed to investigate whether the Alternative Healthy Eating Index (AHEI) and the clinically abbreviated Prime Diet Quality Score (PDQS) are associated with the risk of overall HF, HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF).

methodsOur study included 44,525 men from the Health Professionals Follow-up Study (HPFS) who were free from cardiovascular disease and cancer at baseline. The AHEI and PDQS were computed based on dietary data repeatedly measured using semiquantitative FFQs. HF, HFpEF, and HFrEF were adjudicated based on review of medical records through 2008. Associations of diet quality with incident HF were estimated with multivariate-adjusted Cox proportional hazards models.

resultsDuring 929,911 person-years of follow-up, 803 HF cases were documented, including 184 with HFpEF and 181 with HFrEF among those with ejection fraction (EF) data. Adjusting for potential confounders, we did not observe a significant association between the AHEI and overall HF (HR per SD: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.57) or between the PDQS and overall HF (HR per SD: 0.98; 95% CI: 0.91, 1.06; P-trend = 0.82). Both dietary indices were not significantly associated with HFpEF. However, a higher AHEI was associated with lower risk of HFrEF upon comparison of the extreme quintiles (HR per SD: 0.81; 95% CI: 0.69, 0.96; P-trend = 0.02). Every SD increment in the PDQS was associated with 20% lower risk of HFrEF (HR per SD: 0.80; 95% CI: 0.68, 0.95; P-quadratic = 0.03).

conclusionsA healthy overall diet was associated with lower risk of HFrEF, and associations were similar with the AHEI and PDQS. We did not observe a significant association between dietary indices and either overall HF or HFpEF.

Indexed as

DietFollow-Up StudiesHeart FailureHumansMalePrognosisRisk FactorsStroke VolumeVentricular Function, LeftAHEIdietary qualityheart failureheart failure with preserved ejection fractionheart failure with reduced ejection fractionPDQS

Identifiers

PMID35511594
PMCPMC9348972
OpenAlexW4226280380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.