ArticleJournal of Crohn's & colitis2022
Oral Microbiome of Crohn's Disease Patients With and Without Oral Manifestations.
Article in Journal of Crohn's & colitis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Is the microbiome the answer to inflammatory bowel disease: systematic review.Langenbeck's archives of surgery · 2025Pooled it
- Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study.Inflammatory bowel diseases · 2026Trial
- Metagenomics in the Interplay Among Oral and Gut Dysbiosis.Metabolites · 2026Review
- Revisiting the Oral-Gut Axis: Microbial Symbiosis, Dysbiosis, and Bidirectional Links Between Periodontitis and Inflammatory Bowel Disease.Microorganisms · 2026Review
- Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring.Advanced healthcare materials · 2026Article
- Oral Manifestations in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Oral-Gut Microbiome Axis in Crohn's Disease: A Potential Role of Ectopic Colonization.Microorganisms · 2026Review
- [The Impact of Oral Microecology on the Development of Inflammatory Bowel Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Oral-Gut Microbial Crosstalk and Therapeutic Applications of Bacterial Extracellular Vesicles.Biomolecules · 2025Review
- Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis.The Japanese dental science review · 2025Review
- Oral microbiome and inflammatory bowel disease: New understanding and call to action.World journal of gastroenterology · 2025Review
- Oral Microbial Diversity is Associated with Biologic Treatment and Metabolic Health Status but not with Disease Activity in Patients with Inflammatory Bowel Disease.Crohn's & colitis 360 · 2025Article
- OSaMPle workflow for salivary metaproteomics analysis reveals dysbiosis in inflammatory bowel disease patients.NPJ biofilms and microbiomes · 2025Article
- Oral Microbiota and Inflammatory Bowel Diseases: Detection of Emerging Fungal Pathogens and Herpesvirus.Biomedicines · 2025Article
- Characterization of the salivary microbiome of adults with inflammatory bowel disease.Journal of oral microbiology · 2025Article
- Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases.Mucosal immunology · 2024Review
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- The oral-gut microbiome axis in inflammatory bowel disease: from inside to insight.Frontiers in immunology · 2024Review
- Deciphering salivary microbiome signature in Crohn's disease patients with different factors contributing to dysbiosis.Scientific reports · 2023Article
- Unraveling the Impact of Gut and Oral Microbiome on Gut Health in Inflammatory Bowel Diseases.Nutrients · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsMicrobiome dysbiosis is associated with inflammatory destruction in Crohn's disease [CD]. Although gut microbiome dysbiosis is well established in CD, the oral microbiome is comparatively under-studied. This study aims to characterize the oral microbiome of CD patients with/without oral manifestations.
methodsPatients with CD were recruited with age-, gender- and race-matched controls. Potential confounders such as dental caries and periodontal condition were recorded. The oral microbiome was collected using saliva samples. Microbial DNA was extracted and sequenced using shotgun sequencing. Metagenomic taxonomic and functional profiles were generated and analysed.
resultsThe study recruited 41 patients with CD and 24 healthy controls. Within the CD subjects, 39.0% had oral manifestations with the majority presenting with cobblestoning and/or oral ulcers. Principal coordinate analysis demonstrated distinct oral microbiome profiles between subjects with and without CD, with four key variables responsible for overall oral microbiome variance: [1] diagnosis of CD, [2] concomitant use of steroids, [3] concomitant use of azathioprine and 4] presence of oral ulcers. Thirty-two significant differentially abundant microbial species were identified, with the majority associated with the diagnosis of CD. A predictive model based on differences in the oral microbiome found that the oral microbiome has strong discriminatory function to distinguish subjects with and without CD [AUROC 0.84]. Functional analysis found that an increased representation of microbial enzymes [n = 5] in the butyrate pathway was positively associated with the presence of oral ulcers.
conclusionsThe oral microbiome can aid in the diagnosis of CD and its composition was associated with oral manifestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.